TY - JOUR
T1 - Investigating miRNA subfamilies
T2 - Can they assist in the early diagnosis of acute myocardial infarction?
AU - Sharma, Arun K.
AU - Bisht, Priyanka
AU - Gupta, Bishal
AU - Sayeed Akhtar, M. D.
AU - Shaik Alavudeen, Sirajudeen
AU - Afzal, Obaid
AU - Saleh Altamimi, Abdulmalik
N1 - Publisher Copyright:
© 2023 Elsevier Ltd
PY - 2023/10
Y1 - 2023/10
N2 - This report focuses on small non-coding RNA molecules (miRNAs), which have emerged as potential biomarkers with variable diagnostic values and false-positives in different conditions that limit their clinical preference. Current investigations focus on small non-coding RNA molecules (miRNAs), which have emerged as potential biomarkers with variable diagnostic values and false-positives in different conditions that limit their clinical preference. We thoroughly scrutinize the leading pathology of myocardial infarction and contemporary alterations in miRNAs for their specificity, stability and significant prognostic value at the early stage of acute myocardial infarction (AMI). Based on secondary data analysis, we explore common biomarkers and further investigate included miRNA biomarkers for their specificity, stability and area under the curve (AUC) values. We conclude that a group of novel biomarkers, including miRNA-1, miRNA-208a/b and miRNA-499, could help predict the emergence of AMI at an early stage.
AB - This report focuses on small non-coding RNA molecules (miRNAs), which have emerged as potential biomarkers with variable diagnostic values and false-positives in different conditions that limit their clinical preference. Current investigations focus on small non-coding RNA molecules (miRNAs), which have emerged as potential biomarkers with variable diagnostic values and false-positives in different conditions that limit their clinical preference. We thoroughly scrutinize the leading pathology of myocardial infarction and contemporary alterations in miRNAs for their specificity, stability and significant prognostic value at the early stage of acute myocardial infarction (AMI). Based on secondary data analysis, we explore common biomarkers and further investigate included miRNA biomarkers for their specificity, stability and area under the curve (AUC) values. We conclude that a group of novel biomarkers, including miRNA-1, miRNA-208a/b and miRNA-499, could help predict the emergence of AMI at an early stage.
KW - cardiac biomarkers
KW - early diagnostic
KW - miRNAs
KW - molecular signaling
KW - myocardial infarction
KW - prognosis
UR - http://www.scopus.com/inward/record.url?scp=85166636038&partnerID=8YFLogxK
U2 - 10.1016/j.drudis.2023.103695
DO - 10.1016/j.drudis.2023.103695
M3 - Review article
C2 - 37406730
AN - SCOPUS:85166636038
SN - 1359-6446
VL - 28
JO - Drug Discovery Today
JF - Drug Discovery Today
IS - 10
M1 - 103695
ER -
