Intramolecular Cascade C–S Bond Formation: A Safe and New Strategy for the Synthesis of Riluzole Analogues Catalyzed by K₂S₂O₈

Due to the diverse applications of benzothiazoles as a privileged core in the medical and pharmaceutical industry, a simple and efficient method for synthesizing benzothiazoles via aniline, KSCN, K₂CO₃, and K₂S₂O₈ is very attractive. In this study, the effective and efficient procedure for the synthesis of benzothiazoles derivatives was described. This protocol avoids the use of hazard chemical oxidants, such as bromine, thionyl chloride, iodine, and H₂O₂, and provides an alternative procedure for synthesizing benzothiazoles. K₂S₂O₈ as an oxidant was applied to synthesis of benzothiazoles in good to excellent yields.