Inspiratory Muscle Training in Obstructive Sleep Apnea Associating Diabetic Peripheral Neuropathy: A Randomized Control Study

Objective. This work is aimed at assessing the effects of inspiratory muscle training on lung functions, inspiratory muscle strength, and aerobic capacity in diabetic peripheral neuropathy (DPN) patients with obstructive sleep apnea (OSA). Methods. A randomized control study was performed on 55 patients diagnosed with DPN and OSA. They were assigned to the training group (IMT, n=28) and placebo training group (P-IMT, n=27). Inspiratory muscle strength, lung functions, and aerobic capacity were evaluated before and after 12 weeks postintervention. An electronic inspiratory muscle trainer was conducted, 30 min a session, three times a week for 12 consecutive weeks. Results. From seventy-four patients, 55 have completed the study program. A significant improvement was observed in inspiratory muscle strength (p<0.05) in the IMT group while no changes were observed in the P-IMT group (p>0.05). No changes were observed in the lung function in the two groups (p>0.05). Also, VO2max and VCO2max changed significantly after training in the IMT group (p<0.05) while no changes were observed in the P-IMT group (p>0.05). Other cardiopulmonary exercise tests did not show any significant change in both groups (p>0.05). Conclusions. Based on the outcomes of the study, it was found that inspiratory muscle training improves inspiratory muscle strength and aerobic capacity without a notable effect on lung functions for diabetic patients suffering from DPN and OSA.