TY - JOUR
T1 - Innovations in cancer immunotherapy
T2 - A comprehensive overview of recent breakthroughs and future directions
AU - Hsu, Chou Yi
AU - Pallathadka, Harikumar
AU - Jasim, Saade Abdalkareem
AU - Rizaev, Jasur
AU - Olegovich Bokov, Dmitry
AU - Hjazi, Ahmed
AU - Mahajan, Shriya
AU - Mustafa, Yasser Fakri
AU - Husseen, Beneen
AU - Jawad, Mohammed Abed
N1 - Publisher Copyright:
© 2024 Elsevier B.V.
PY - 2025/2
Y1 - 2025/2
N2 - A major advance in cancer treatment has been the development and refinement of cancer immunotherapy. The discovery of immunotherapies for a wide range of cancers has revolutionized cancer treatment paradigms. Despite relapse or refractory disease, immunotherapy approaches can prolong the life expectancy of metastatic cancer patients. Multiple therapeutic approaches and agents are currently being developed to manipulate various aspects of the immune system. Oncolytic viruses, cancer vaccines, adoptive cell therapies, monoclonal antibodies, cytokine therapies, and inhibitors of immune checkpoints have all proven successful in clinical trials. There are several types of immunotherapeutic approaches available for treating cancer, and others are being tested in preclinical and clinical settings. Immunotherapy has proven successful, and many agents and strategies have been developed to improve its effectiveness. The purpose of this article is to present a comprehensive overview of current immunotherapy approaches used to treat cancer. Cancer immunotherapy advancements, emerging patterns, constraints, and potential future breakthroughs are also discussed.
AB - A major advance in cancer treatment has been the development and refinement of cancer immunotherapy. The discovery of immunotherapies for a wide range of cancers has revolutionized cancer treatment paradigms. Despite relapse or refractory disease, immunotherapy approaches can prolong the life expectancy of metastatic cancer patients. Multiple therapeutic approaches and agents are currently being developed to manipulate various aspects of the immune system. Oncolytic viruses, cancer vaccines, adoptive cell therapies, monoclonal antibodies, cytokine therapies, and inhibitors of immune checkpoints have all proven successful in clinical trials. There are several types of immunotherapeutic approaches available for treating cancer, and others are being tested in preclinical and clinical settings. Immunotherapy has proven successful, and many agents and strategies have been developed to improve its effectiveness. The purpose of this article is to present a comprehensive overview of current immunotherapy approaches used to treat cancer. Cancer immunotherapy advancements, emerging patterns, constraints, and potential future breakthroughs are also discussed.
KW - CAR T-cells
KW - Cancer immunotherapy
KW - Cancer vaccines
KW - Cytokine therapies
KW - Immune checkpoint inhibitors
KW - Monoclonal antibodies
KW - Oncolytic viro-immunotherapy
UR - http://www.scopus.com/inward/record.url?scp=85212321107&partnerID=8YFLogxK
U2 - 10.1016/j.critrevonc.2024.104588
DO - 10.1016/j.critrevonc.2024.104588
M3 - Review article
C2 - 39667718
AN - SCOPUS:85212321107
SN - 1040-8428
VL - 206
JO - Critical Reviews in Oncology/Hematology
JF - Critical Reviews in Oncology/Hematology
M1 - 104588
ER -
