TY - JOUR
T1 - Inflammatory lung diseases
T2 - a clinical and scientific review of the latest advances and challenges
AU - Katamesh, Ahmed A.
AU - Almansour, Khaled
AU - Hassoun, Shimaa M.
AU - Sayed, Ossama M.
AU - Break, Mohammed Khaled Bin
AU - Zaki, Randa Mohammed
AU - Afzal, Obaid
AU - Radwan, Amr
N1 - Publisher Copyright:
© The Author(s) under exclusive licence to Maj Institute of Pharmacology Polish Academy of Sciences 2025.
PY - 2025/8
Y1 - 2025/8
N2 - Inflammatory lung diseases, including chronic obstructive pulmonary disease (COPD), asthma, pulmonary sarcoidosis, and interstitial lung diseases (ILDs), represent a significant cause of morbidity and mortality globally. These conditions are characterized by chronic inflammation and tissue damage, leading to substantial respiratory compromise and impairing quality of life. This review aims to provide a comprehensive overview of pathogenesis, clinical features, and diagnostic approaches for inflammatory lung diseases, emphasizing their shared and distinct characteristics. The review synthesizes current literature on the genetic predisposition, environmental exposures, and immune responses involved in the development and progression of inflammatory lung diseases. It also examines the classification and staging of these conditions to highlight the importance of accurate diagnosis and effective management. Key findings include the complex interplay of numerous factors that contribute to disease development and progression, as well as an analysis of classification and staging systems that support clinical practice. By elucidating the underlying mechanisms and clinical features of inflammatory lung diseases, this review aims to inform the development of novel therapeutic strategies and enhance patient outcomes.
AB - Inflammatory lung diseases, including chronic obstructive pulmonary disease (COPD), asthma, pulmonary sarcoidosis, and interstitial lung diseases (ILDs), represent a significant cause of morbidity and mortality globally. These conditions are characterized by chronic inflammation and tissue damage, leading to substantial respiratory compromise and impairing quality of life. This review aims to provide a comprehensive overview of pathogenesis, clinical features, and diagnostic approaches for inflammatory lung diseases, emphasizing their shared and distinct characteristics. The review synthesizes current literature on the genetic predisposition, environmental exposures, and immune responses involved in the development and progression of inflammatory lung diseases. It also examines the classification and staging of these conditions to highlight the importance of accurate diagnosis and effective management. Key findings include the complex interplay of numerous factors that contribute to disease development and progression, as well as an analysis of classification and staging systems that support clinical practice. By elucidating the underlying mechanisms and clinical features of inflammatory lung diseases, this review aims to inform the development of novel therapeutic strategies and enhance patient outcomes.
UR - http://www.scopus.com/inward/record.url?scp=105007877558&partnerID=8YFLogxK
U2 - 10.1007/s43440-025-00749-y
DO - 10.1007/s43440-025-00749-y
M3 - Review article
C2 - 40512413
AN - SCOPUS:105007877558
SN - 1734-1140
VL - 77
SP - 889
EP - 906
JO - Pharmacological Reports
JF - Pharmacological Reports
IS - 4
ER -
