Abstract
Objective: This study was aimed at characterizing alterations in the immunohistochemical expression of p16 in carcinoma ex-pleomorphic adenomas. Study Design: A selected series of 27 cases of carcinoma ex-pleomorphic adenomas were examined. R esults: The results showed that p16 expression in non tumour duct cells was strongly positive nuclear staining in 23 (85%) cases out of 27 cases, that 3 (11.1%) had moderate staining, and that 1 (3.7%) had weak staining. p16 expression in carcinoma ex-pleomorphic adenomas was indicated as a negative nuclear staining in 22 (81.4%) cases out of 27cases, and 5 (18.5%) cases expressed moderate staining. C onclusion: This study suggests that alteration of p16 expression is detected in carcinoma ex-pleomorphic adenomas. p16 has a role in development of carcinoma ex-pleomorphic adenomas.
| Original language | English |
|---|---|
| Pages (from-to) | 3054-3056 |
| Number of pages | 3 |
| Journal | Journal of Clinical and Diagnostic Research |
| Volume | 7 |
| Issue number | 12 |
| DOIs | |
| State | Published - 15 Dec 2013 |
Keywords
- CDKN2 gene
- p16 expression
