Hydroxyapatite-based bio-ceramic of ternary nanocomposites containing cuprous oxide/graphene oxide for biomedical applications

E. H. Eldrehmy; Y. S. Alghamdi; H. H. Amer; M. H. Yassin; S. A. Mostafa; Moustapha Eid Moustapha; A. A. Menazea

doi:10.1016/j.diamond.2022.109121

Hydroxyapatite-based bio-ceramic of ternary nanocomposites containing cuprous oxide/graphene oxide for biomedical applications

E. H. Eldrehmy, Y. S. Alghamdi, H. H. Amer, M. H. Yassin, S. A. Mostafa, Moustapha Eid Moustapha, A. A. Menazea

Chemistry

Research output: Contribution to journal › Article › peer-review

11 Scopus citations

Abstract

The nanocomposites (NCs) contain a hybrid matrix and reinforcing material that could improve the physicochemical and biological properties of individual compounds. HAP, Cu₂O, and GO were prepared separately and combined to fabricate nanocomposite (NCs). The hexagonal symmetry of HAP and the cubic symmetry of Cu₂O were confirmed using XRD analysis. The different scanning techniques detected HAP with nanorod shape. The length decreased from 50 to 27 nm. Rv reached 208.4 nm. The effect of the ternary nanocomposite (TNC) against S. aureus and E. coli reached 14.1 ± 1.1 and 13.2 ± 1.2 mm, respectively. Furthermore, the cell viability towards the human cell line is around 103 ± 4%. The enhancement in antibacterial behavior and cell viability confirms the biocompatibility of the TNC to be encouraged for use in biomedical utilizations such as bone regeneration.

Original language	English
Article number	109121
Journal	Diamond and Related Materials
Volume	126
DOIs	https://doi.org/10.1016/j.diamond.2022.109121
State	Published - Jun 2022

Keywords

Antibacterial
Cell viability
Cuprous oxide
Graphene oxide
Hydroxyapatite

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10.1016/j.diamond.2022.109121

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@article{b176f481a4f14f17905169cfa05dc000,

title = "Hydroxyapatite-based bio-ceramic of ternary nanocomposites containing cuprous oxide/graphene oxide for biomedical applications",

abstract = "The nanocomposites (NCs) contain a hybrid matrix and reinforcing material that could improve the physicochemical and biological properties of individual compounds. HAP, Cu2O, and GO were prepared separately and combined to fabricate nanocomposite (NCs). The hexagonal symmetry of HAP and the cubic symmetry of Cu2O were confirmed using XRD analysis. The different scanning techniques detected HAP with nanorod shape. The length decreased from 50 to 27 nm. Rv reached 208.4 nm. The effect of the ternary nanocomposite (TNC) against S. aureus and E. coli reached 14.1 ± 1.1 and 13.2 ± 1.2 mm, respectively. Furthermore, the cell viability towards the human cell line is around 103 ± 4\%. The enhancement in antibacterial behavior and cell viability confirms the biocompatibility of the TNC to be encouraged for use in biomedical utilizations such as bone regeneration.",

keywords = "Antibacterial, Cell viability, Cuprous oxide, Graphene oxide, Hydroxyapatite",

author = "Eldrehmy, \{E. H.\} and Alghamdi, \{Y. S.\} and Amer, \{H. H.\} and Yassin, \{M. H.\} and Mostafa, \{S. A.\} and Moustapha, \{Moustapha Eid\} and Menazea, \{A. A.\}",

note = "Publisher Copyright: {\textcopyright} 2022 Elsevier B.V.",

year = "2022",

month = jun,

doi = "10.1016/j.diamond.2022.109121",

language = "English",

volume = "126",

journal = "Diamond and Related Materials",

issn = "0925-9635",

publisher = "Elsevier B.V.",

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AU - Eldrehmy, E. H.

AU - Alghamdi, Y. S.

AU - Amer, H. H.

AU - Yassin, M. H.

AU - Mostafa, S. A.

AU - Moustapha, Moustapha Eid

AU - Menazea, A. A.

PY - 2022/6

Y1 - 2022/6

N2 - The nanocomposites (NCs) contain a hybrid matrix and reinforcing material that could improve the physicochemical and biological properties of individual compounds. HAP, Cu2O, and GO were prepared separately and combined to fabricate nanocomposite (NCs). The hexagonal symmetry of HAP and the cubic symmetry of Cu2O were confirmed using XRD analysis. The different scanning techniques detected HAP with nanorod shape. The length decreased from 50 to 27 nm. Rv reached 208.4 nm. The effect of the ternary nanocomposite (TNC) against S. aureus and E. coli reached 14.1 ± 1.1 and 13.2 ± 1.2 mm, respectively. Furthermore, the cell viability towards the human cell line is around 103 ± 4%. The enhancement in antibacterial behavior and cell viability confirms the biocompatibility of the TNC to be encouraged for use in biomedical utilizations such as bone regeneration.

AB - The nanocomposites (NCs) contain a hybrid matrix and reinforcing material that could improve the physicochemical and biological properties of individual compounds. HAP, Cu2O, and GO were prepared separately and combined to fabricate nanocomposite (NCs). The hexagonal symmetry of HAP and the cubic symmetry of Cu2O were confirmed using XRD analysis. The different scanning techniques detected HAP with nanorod shape. The length decreased from 50 to 27 nm. Rv reached 208.4 nm. The effect of the ternary nanocomposite (TNC) against S. aureus and E. coli reached 14.1 ± 1.1 and 13.2 ± 1.2 mm, respectively. Furthermore, the cell viability towards the human cell line is around 103 ± 4%. The enhancement in antibacterial behavior and cell viability confirms the biocompatibility of the TNC to be encouraged for use in biomedical utilizations such as bone regeneration.

KW - Antibacterial

KW - Cell viability

KW - Cuprous oxide

KW - Graphene oxide

KW - Hydroxyapatite

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U2 - 10.1016/j.diamond.2022.109121

DO - 10.1016/j.diamond.2022.109121

M3 - Article

AN - SCOPUS:85131401490

SN - 0925-9635

VL - 126

JO - Diamond and Related Materials

JF - Diamond and Related Materials

M1 - 109121

ER -

Hydroxyapatite-based bio-ceramic of ternary nanocomposites containing cuprous oxide/graphene oxide for biomedical applications

Abstract

Keywords

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