HPTLC Fingerprint Profile and Identification of Antidiabetic and Antioxidant Leads from Bauhinia rufescens L

Wadah Osman; Mona S. Mohammed; Hassan S. Khalid; Abdelkhalig Muddathir; Shaza W. Shantier; Bashier Osman; Iman Abdoon

doi:10.1155/2020/3201463

HPTLC Fingerprint Profile and Identification of Antidiabetic and Antioxidant Leads from Bauhinia rufescens L

Wadah Osman
, Mona S. Mohammed
, Hassan S. Khalid
, Abdelkhalig Muddathir
, Shaza W. Shantier
, Bashier Osman
, Iman Abdoon

University of Khartoum

Research output: Contribution to journal › Article › peer-review

13 Scopus citations

Abstract

Diabetes is one of the world's major health problems, and many reports have supported the role of oxidative stress in the pathogenesis of both type 1 and type 2 diabetes. The present study aims to evaluate the antidiabetic and antioxidant activity of Bauhinia rufescens, a plant used in Sudanese folkloric medicine for the treatment of diabetes. It was also aimed to identify isolates and characterize the bioactive antidiabetic and antioxidant compounds using bioactivity-guided fractionation followed by high-performance thin-layer chromatography (HPTLC) autobiography, liquid chromatography-mass spectrometric analysis, and nuclear magnetic resonance (NMR). Two potential compounds were successfully isolated and identified which may provide new leads for more potent analogues in drug discovery.

Original language	English
Article number	3201463
Journal	Advances in Pharmacological and Pharmaceutical Sciences
Volume	2020
DOIs	https://doi.org/10.1155/2020/3201463
State	Published - 2020
Externally published	Yes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Access to Document

10.1155/2020/3201463

Cite this

@article{e8475e9aa0224278b1f23ef9759f545d,

title = "HPTLC Fingerprint Profile and Identification of Antidiabetic and Antioxidant Leads from Bauhinia rufescens L",

abstract = "Diabetes is one of the world's major health problems, and many reports have supported the role of oxidative stress in the pathogenesis of both type 1 and type 2 diabetes. The present study aims to evaluate the antidiabetic and antioxidant activity of Bauhinia rufescens, a plant used in Sudanese folkloric medicine for the treatment of diabetes. It was also aimed to identify isolates and characterize the bioactive antidiabetic and antioxidant compounds using bioactivity-guided fractionation followed by high-performance thin-layer chromatography (HPTLC) autobiography, liquid chromatography-mass spectrometric analysis, and nuclear magnetic resonance (NMR). Two potential compounds were successfully isolated and identified which may provide new leads for more potent analogues in drug discovery.",

author = "Wadah Osman and Mohammed, \{Mona S.\} and Khalid, \{Hassan S.\} and Abdelkhalig Muddathir and Shantier, \{Shaza W.\} and Bashier Osman and Iman Abdoon",

note = "Publisher Copyright: {\textcopyright} 2020 Wadah osman et al.",

year = "2020",

doi = "10.1155/2020/3201463",

language = "English",

volume = "2020",

journal = "Advances in Pharmacological and Pharmaceutical Sciences",

issn = "2633-4682",

publisher = "John Wiley and Sons Ltd",

}

TY - JOUR

T1 - HPTLC Fingerprint Profile and Identification of Antidiabetic and Antioxidant Leads from Bauhinia rufescens L

AU - Osman, Wadah

AU - Mohammed, Mona S.

AU - Khalid, Hassan S.

AU - Muddathir, Abdelkhalig

AU - Shantier, Shaza W.

AU - Osman, Bashier

AU - Abdoon, Iman

PY - 2020

Y1 - 2020

N2 - Diabetes is one of the world's major health problems, and many reports have supported the role of oxidative stress in the pathogenesis of both type 1 and type 2 diabetes. The present study aims to evaluate the antidiabetic and antioxidant activity of Bauhinia rufescens, a plant used in Sudanese folkloric medicine for the treatment of diabetes. It was also aimed to identify isolates and characterize the bioactive antidiabetic and antioxidant compounds using bioactivity-guided fractionation followed by high-performance thin-layer chromatography (HPTLC) autobiography, liquid chromatography-mass spectrometric analysis, and nuclear magnetic resonance (NMR). Two potential compounds were successfully isolated and identified which may provide new leads for more potent analogues in drug discovery.

AB - Diabetes is one of the world's major health problems, and many reports have supported the role of oxidative stress in the pathogenesis of both type 1 and type 2 diabetes. The present study aims to evaluate the antidiabetic and antioxidant activity of Bauhinia rufescens, a plant used in Sudanese folkloric medicine for the treatment of diabetes. It was also aimed to identify isolates and characterize the bioactive antidiabetic and antioxidant compounds using bioactivity-guided fractionation followed by high-performance thin-layer chromatography (HPTLC) autobiography, liquid chromatography-mass spectrometric analysis, and nuclear magnetic resonance (NMR). Two potential compounds were successfully isolated and identified which may provide new leads for more potent analogues in drug discovery.

UR - https://www.scopus.com/pages/publications/85088831330

U2 - 10.1155/2020/3201463

DO - 10.1155/2020/3201463

M3 - Article

AN - SCOPUS:85088831330

SN - 2633-4682

VL - 2020

JO - Advances in Pharmacological and Pharmaceutical Sciences

JF - Advances in Pharmacological and Pharmaceutical Sciences

M1 - 3201463

ER -

HPTLC Fingerprint Profile and Identification of Antidiabetic and Antioxidant Leads from Bauhinia rufescens L

Abstract

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this