HPTLC Fingerprint Profile and Identification of Antidiabetic and Antioxidant Leads from Bauhinia rufescens L

Wadah Osman; Mona S. Mohammed; Hassan S. Khalid; Abdelkhalig Muddathir; Shaza W. Shantier; Bashier Osman; Iman Abdoon

doi:10.1155/2020/3201463

HPTLC Fingerprint Profile and Identification of Antidiabetic and Antioxidant Leads from Bauhinia rufescens L

Wadah Osman, Mona S. Mohammed, Hassan S. Khalid, Abdelkhalig Muddathir, Shaza W. Shantier, Bashier Osman, Iman Abdoon

University of Khartoum

Research output: Contribution to journal › Article › peer-review

12 Scopus citations

Abstract

Diabetes is one of the world's major health problems, and many reports have supported the role of oxidative stress in the pathogenesis of both type 1 and type 2 diabetes. The present study aims to evaluate the antidiabetic and antioxidant activity of Bauhinia rufescens, a plant used in Sudanese folkloric medicine for the treatment of diabetes. It was also aimed to identify isolates and characterize the bioactive antidiabetic and antioxidant compounds using bioactivity-guided fractionation followed by high-performance thin-layer chromatography (HPTLC) autobiography, liquid chromatography-mass spectrometric analysis, and nuclear magnetic resonance (NMR). Two potential compounds were successfully isolated and identified which may provide new leads for more potent analogues in drug discovery.

Original language	English
Article number	3201463
Journal	Advances in Pharmacological and Pharmaceutical Sciences
Volume	2020
DOIs	https://doi.org/10.1155/2020/3201463
State	Published - 2020
Externally published	Yes

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title = "HPTLC Fingerprint Profile and Identification of Antidiabetic and Antioxidant Leads from Bauhinia rufescens L",

abstract = "Diabetes is one of the world's major health problems, and many reports have supported the role of oxidative stress in the pathogenesis of both type 1 and type 2 diabetes. The present study aims to evaluate the antidiabetic and antioxidant activity of Bauhinia rufescens, a plant used in Sudanese folkloric medicine for the treatment of diabetes. It was also aimed to identify isolates and characterize the bioactive antidiabetic and antioxidant compounds using bioactivity-guided fractionation followed by high-performance thin-layer chromatography (HPTLC) autobiography, liquid chromatography-mass spectrometric analysis, and nuclear magnetic resonance (NMR). Two potential compounds were successfully isolated and identified which may provide new leads for more potent analogues in drug discovery.",

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year = "2020",

doi = "10.1155/2020/3201463",

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AU - Osman, Wadah

AU - Mohammed, Mona S.

AU - Khalid, Hassan S.

AU - Muddathir, Abdelkhalig

AU - Shantier, Shaza W.

AU - Osman, Bashier

AU - Abdoon, Iman

PY - 2020

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AB - Diabetes is one of the world's major health problems, and many reports have supported the role of oxidative stress in the pathogenesis of both type 1 and type 2 diabetes. The present study aims to evaluate the antidiabetic and antioxidant activity of Bauhinia rufescens, a plant used in Sudanese folkloric medicine for the treatment of diabetes. It was also aimed to identify isolates and characterize the bioactive antidiabetic and antioxidant compounds using bioactivity-guided fractionation followed by high-performance thin-layer chromatography (HPTLC) autobiography, liquid chromatography-mass spectrometric analysis, and nuclear magnetic resonance (NMR). Two potential compounds were successfully isolated and identified which may provide new leads for more potent analogues in drug discovery.

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HPTLC Fingerprint Profile and Identification of Antidiabetic and Antioxidant Leads from Bauhinia rufescens L

Abstract

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