Highly reduced graphene oxide-phosphomolybdic acid catalyzed synthesis of quinazoline derivatives in deep eutectic solvent: An expeditious approach

Nanocomposite of highly reduced graphene oxide (HRG) with phosphomolybdic acid (PMoA) exhibits excellent catalytic activities toward the synthesis of quinazoline derivatives. The hybrid catalyst is cost effective, easy to apply and has shown encouraging results due to the combined effect of unique structural characteristics of HRG and efficient catalytic activity of PMoA. The prepared nanocatalyst was characterized by FTIR spectroscopy, X-ray diffraction study, Brunauer-Emmett-Teller, and scanning electron microscope analyses. In the present study, we have reported the synthesis of quinazoline derivatives through a three-component reaction system using a new strategy of recyclable nanocatalyst in another recyclable green solvent, namely, HRG-PMoA and deep eutectic solvent (DES), respectively. Hence, this concept adopted the doubly green approach and the process becomes expeditious. In conclusion, catalyst and DES were reused up to four times devoid of any significant change in its activity.