Hepatitis C virus infections in oral lichen planus: a systematic review and meta-analysis

N. A. Alaizari; S. A. Al-Maweri; H. M. Al-Shamiri; B. Tarakji; B. Shugaa-Addin

doi:10.1111/adj.12382

Hepatitis C virus infections in oral lichen planus: a systematic review and meta-analysis

N. A. Alaizari
, S. A. Al-Maweri
, H. M. Al-Shamiri
, B. Tarakji
, B. Shugaa-Addin

Al-Farabi Colleges

Research output: Contribution to journal › Article › peer-review

89 Scopus citations

Abstract

BACKGROUND: A role for hepatitis C virus in oral lichen planus has been postulated. This systematic review and meta-analysis of the existing epidemiological studies was conducted to determine if there is a correlation between oral lichen planus and hepatitis C virus infection.

METHODS: We examined the association between hepatitis C virus and oral lichen planus by conducting a systematic review and meta-analysis of case-control studies that examined the prevalence of anti-HCV antibodies in the serum of cases and controls. We searched PubMed, Embase and The Cochrane Library databases from 2005 to January 2015. Associations were measured using random-effect odds ratios (ORs) combined with 95% confidence intervals.

RESULTS: Nineteen eligible studies, encompassing 1807 cases of OLP and 2519 controls, were retrieved and included in this review. The summary estimate OR for all studies was 6.07 (95% CI: 2.73-13.48), showing a statistically significant difference in the proportion of HCV seropositivity among oral lichen planus patients, compared with controls and substantial heterogeneity between studies (I(2) = 65%) as a result of a variety of geographical distributions.

CONCLUSIONS: The association of hepatitis C virus infection with oral lichen planus emphasizes the importance of hepatitis C virus screening in oral lichen planus patients.

Original language	English
Pages (from-to)	282-287
Number of pages	6
Journal	Australian Dental Journal
Volume	61
Issue number	3
DOIs	https://doi.org/10.1111/adj.12382
State	Published - 1 Sep 2016
Externally published	Yes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Hepatitis C
lichen planus
meta-analysis
oral
systematic review

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10.1111/adj.12382

Cite this

@article{781e65aba5d74e05aaab8563cf1a3d5f,

title = "Hepatitis C virus infections in oral lichen planus: a systematic review and meta-analysis",

abstract = "BACKGROUND: A role for hepatitis C virus in oral lichen planus has been postulated. This systematic review and meta-analysis of the existing epidemiological studies was conducted to determine if there is a correlation between oral lichen planus and hepatitis C virus infection.METHODS: We examined the association between hepatitis C virus and oral lichen planus by conducting a systematic review and meta-analysis of case-control studies that examined the prevalence of anti-HCV antibodies in the serum of cases and controls. We searched PubMed, Embase and The Cochrane Library databases from 2005 to January 2015. Associations were measured using random-effect odds ratios (ORs) combined with 95\% confidence intervals.RESULTS: Nineteen eligible studies, encompassing 1807 cases of OLP and 2519 controls, were retrieved and included in this review. The summary estimate OR for all studies was 6.07 (95\% CI: 2.73-13.48), showing a statistically significant difference in the proportion of HCV seropositivity among oral lichen planus patients, compared with controls and substantial heterogeneity between studies (I(2) = 65\%) as a result of a variety of geographical distributions.CONCLUSIONS: The association of hepatitis C virus infection with oral lichen planus emphasizes the importance of hepatitis C virus screening in oral lichen planus patients.",

keywords = "Hepatitis C, lichen planus, meta-analysis, oral, systematic review",

author = "Alaizari, \{N. A.\} and Al-Maweri, \{S. A.\} and Al-Shamiri, \{H. M.\} and B. Tarakji and B. Shugaa-Addin",

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year = "2016",

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doi = "10.1111/adj.12382",

language = "English",

volume = "61",

pages = "282--287",

journal = "Australian Dental Journal",

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TY - JOUR

T1 - Hepatitis C virus infections in oral lichen planus

T2 - a systematic review and meta-analysis

AU - Alaizari, N. A.

AU - Al-Maweri, S. A.

AU - Al-Shamiri, H. M.

AU - Tarakji, B.

AU - Shugaa-Addin, B.

PY - 2016/9/1

Y1 - 2016/9/1

N2 - BACKGROUND: A role for hepatitis C virus in oral lichen planus has been postulated. This systematic review and meta-analysis of the existing epidemiological studies was conducted to determine if there is a correlation between oral lichen planus and hepatitis C virus infection.METHODS: We examined the association between hepatitis C virus and oral lichen planus by conducting a systematic review and meta-analysis of case-control studies that examined the prevalence of anti-HCV antibodies in the serum of cases and controls. We searched PubMed, Embase and The Cochrane Library databases from 2005 to January 2015. Associations were measured using random-effect odds ratios (ORs) combined with 95% confidence intervals.RESULTS: Nineteen eligible studies, encompassing 1807 cases of OLP and 2519 controls, were retrieved and included in this review. The summary estimate OR for all studies was 6.07 (95% CI: 2.73-13.48), showing a statistically significant difference in the proportion of HCV seropositivity among oral lichen planus patients, compared with controls and substantial heterogeneity between studies (I(2) = 65%) as a result of a variety of geographical distributions.CONCLUSIONS: The association of hepatitis C virus infection with oral lichen planus emphasizes the importance of hepatitis C virus screening in oral lichen planus patients.

AB - BACKGROUND: A role for hepatitis C virus in oral lichen planus has been postulated. This systematic review and meta-analysis of the existing epidemiological studies was conducted to determine if there is a correlation between oral lichen planus and hepatitis C virus infection.METHODS: We examined the association between hepatitis C virus and oral lichen planus by conducting a systematic review and meta-analysis of case-control studies that examined the prevalence of anti-HCV antibodies in the serum of cases and controls. We searched PubMed, Embase and The Cochrane Library databases from 2005 to January 2015. Associations were measured using random-effect odds ratios (ORs) combined with 95% confidence intervals.RESULTS: Nineteen eligible studies, encompassing 1807 cases of OLP and 2519 controls, were retrieved and included in this review. The summary estimate OR for all studies was 6.07 (95% CI: 2.73-13.48), showing a statistically significant difference in the proportion of HCV seropositivity among oral lichen planus patients, compared with controls and substantial heterogeneity between studies (I(2) = 65%) as a result of a variety of geographical distributions.CONCLUSIONS: The association of hepatitis C virus infection with oral lichen planus emphasizes the importance of hepatitis C virus screening in oral lichen planus patients.

KW - Hepatitis C

KW - lichen planus

KW - meta-analysis

KW - oral

KW - systematic review

UR - https://www.scopus.com/pages/publications/84984808182

U2 - 10.1111/adj.12382

DO - 10.1111/adj.12382

M3 - Article

C2 - 26475515

AN - SCOPUS:84984808182

SN - 0045-0421

VL - 61

SP - 282

EP - 287

JO - Australian Dental Journal

JF - Australian Dental Journal

IS - 3

ER -

Hepatitis C virus infections in oral lichen planus: a systematic review and meta-analysis

Abstract

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Keywords

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