Green synthesis and antimicrobial evaluation of Ag/TiO2 and Ag/SeO2 Core-Shell nanocomposites using r. Officinalis extract: A combined experimental and docking study

Yasmeen A.S. Hameed, Albandary Almahri, Adel I. Alalawy, Saham F. Ibarhiam, Nada D. Alkhathami, Hadeer Mattar, Wael M. Alamoudi, Nashwa M. El-Metwaly

Research output: Contribution to journalArticlepeer-review

3 Scopus citations

Abstract

The escalating threat of antibiotic resistance necessitates the development of novel, sustainable antibacterial agents. This study investigates the potential of utilizing Rosmarinus officinalis leaf extracts to synthesize Ag/TiO2 and Ag/SeO2 nanocomposites. R. officinalis extract, a rich source of phenolic and flavonoid compounds, effectively and safely acts as a reducing and capping agent for the green synthesis of Ag/TiO2 and Ag/SeO2 nanocomposites. Characterization of nanocomposites revealed the nanoparticles’ nanoscale size, ranging from 43.34 to 96.58 nm for Ag/TiO2 and 8.04 to 21.72 nm for Ag/SeO2. Both types of nanoparticles exhibited a spherical morphology and distinct crystalline structure. The nanoparticles demonstrated significant antibacterial properties against multiple bacterial strains. The effective concentration for antibacterial activity was determined to be 30.99 mg/mL for Ag-TiO2 and 32.41 mg/mL for Ag-SeO2 nanoparticles. The surface charge of the nanoparticles was measured to be −14.0 mV for Ag-TiO2 and −15.4 mV for Ag/SeO2. Molecular docking simulations investigated the interactions between rosmarinic acid, its derivatives, and the antibiotic cefotaxime with a bacterial protein (e.g., DNA gyrase). These simulations provided insights into the distinct antibacterial mechanisms of these compounds. Briefly, this research highlights the potential of R. officinalis-derived nanocomposites as promising antibacterial agents. The eco-friendly synthesis and promising results pave the way for their development and application in medicine, biochemistry, and environmental fields.

Original languageEnglish
Article number122390
JournalInorganica Chimica Acta
Volume574
DOIs
StatePublished - 1 Jan 2025

Keywords

  • Ag/TiO & Ag/SeO nanocomposites
  • Antimicrobial evaluation
  • Molecular docking simulations
  • Rosmarinus officinalis extract

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