TY - JOUR
T1 - Galangin as an inflammatory response modulator
T2 - An updated overview and therapeutic potential
AU - Thapa, Riya
AU - Afzal, Obaid
AU - Saleh Altamimi, Abdulmalik
AU - Goyal, Ahsas
AU - Almalki, Waleed Hassan
AU - Alzarea, Sami I.
AU - Kazmi, Imran
AU - Jakhmola, Vikash
AU - Singh, Sachin Kumar
AU - Dua, Kamal
AU - Gilhotra, Ritu
AU - Gupta, Gaurav
N1 - Publisher Copyright:
© 2023 Elsevier B.V.
PY - 2023/6/1
Y1 - 2023/6/1
N2 - Numerous chronic diseases, such as cancer, diabetes, rheumatoid arthritis, cardiovascular disease, and gastrointestinal disorders, all have an inflammation-based etiology. In cellular and animal models of inflammation, flavonols were used to show potent anti-inflammatory activity. The flavonols enhanced the synthesis of the anti-inflammatory cytokines transforming growth factor and interleukin-10 (IL-10) and reduced the synthesis of the prostaglandins IL-6, tumor necrosis factor-alpha (TNF-α), and prostaglandin E2 (PGE2), IL-1. Galangin (GAL), a natural flavonol, has a strong ability to control apoptosis and inflammation. GAL was discovered to suppress extracellular signal-regulated kinase (ERK) and nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB)p65 phosphorylation, which results in anti-inflammatory actions. Arthritis, inflammatory bronchitis, stroke, and cognitive dysfunction have all been treated with GAL. The current review aimed to demonstrate the anti-inflammatory properties of GAL and their protective effects in treating various chronic illnesses, including those of the heart, brain, skin, lungs, liver, and inflammatory bowel diseases.
AB - Numerous chronic diseases, such as cancer, diabetes, rheumatoid arthritis, cardiovascular disease, and gastrointestinal disorders, all have an inflammation-based etiology. In cellular and animal models of inflammation, flavonols were used to show potent anti-inflammatory activity. The flavonols enhanced the synthesis of the anti-inflammatory cytokines transforming growth factor and interleukin-10 (IL-10) and reduced the synthesis of the prostaglandins IL-6, tumor necrosis factor-alpha (TNF-α), and prostaglandin E2 (PGE2), IL-1. Galangin (GAL), a natural flavonol, has a strong ability to control apoptosis and inflammation. GAL was discovered to suppress extracellular signal-regulated kinase (ERK) and nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB)p65 phosphorylation, which results in anti-inflammatory actions. Arthritis, inflammatory bronchitis, stroke, and cognitive dysfunction have all been treated with GAL. The current review aimed to demonstrate the anti-inflammatory properties of GAL and their protective effects in treating various chronic illnesses, including those of the heart, brain, skin, lungs, liver, and inflammatory bowel diseases.
KW - Cardiac inflammation
KW - Flavonoid
KW - Galangin
KW - Nephritis
KW - Neuroinflammation
UR - http://www.scopus.com/inward/record.url?scp=85153497508&partnerID=8YFLogxK
U2 - 10.1016/j.cbi.2023.110482
DO - 10.1016/j.cbi.2023.110482
M3 - Review article
C2 - 37044286
AN - SCOPUS:85153497508
SN - 0009-2797
VL - 378
JO - Chemico-Biological Interactions
JF - Chemico-Biological Interactions
M1 - 110482
ER -
