Flavonoids from Leucanthemopsis trifurcatum leaves and their cytotoxic activity

Wael M. Abdel-Mageed; Ahmed A. Attia; Muneera S.M. Al-Saleem; Maged S. Abdel-Kader; Krishna Bolla; Samir A. Ross

Flavonoids from Leucanthemopsis trifurcatum leaves and their cytotoxic activity

Wael M. Abdel-Mageed
, Ahmed A. Attia
, Muneera S.M. Al-Saleem
, Maged S. Abdel-Kader
, Krishna Bolla
, Samir A. Ross

Fharmacognosy

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Abstract

A radical scavenging guided phytochemical study on the leaf of Leucanthemopsis trifurcatum afforded twelve flavonoids (1-12). The structures of the isolated compounds were elucidated on the basis of spectroscopic evidences and correlated with known compounds. The cytotoxic activity of the isolated compounds was evaluated against human Hela and MCF-7 cell lines. Compound 1 displays the strongest cytotoxic activity with IC₅₀ values of 10.3 (Hela) and 12.2 µM (MCF-7).

Original language	English
Pages (from-to)	1839-1843
Number of pages	5
Journal	International Journal of Pharmacognosy and Phytochemical Research
Volume	8
Issue number	11
State	Published - Nov 2016

Keywords

Chrysanthemum macrocephalum
Cytotoxicity
Flavonoids
Leucanthemopsis trifurcatum

Cite this

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title = "Flavonoids from Leucanthemopsis trifurcatum leaves and their cytotoxic activity",

abstract = "A radical scavenging guided phytochemical study on the leaf of Leucanthemopsis trifurcatum afforded twelve flavonoids (1-12). The structures of the isolated compounds were elucidated on the basis of spectroscopic evidences and correlated with known compounds. The cytotoxic activity of the isolated compounds was evaluated against human Hela and MCF-7 cell lines. Compound 1 displays the strongest cytotoxic activity with IC50 values of 10.3 (Hela) and 12.2 µM (MCF-7).",

keywords = "Chrysanthemum macrocephalum, Cytotoxicity, Flavonoids, Leucanthemopsis trifurcatum",

author = "Abdel-Mageed, \{Wael M.\} and Attia, \{Ahmed A.\} and Al-Saleem, \{Muneera S.M.\} and Abdel-Kader, \{Maged S.\} and Krishna Bolla and Ross, \{Samir A.\}",

year = "2016",

month = nov,

language = "English",

volume = "8",

pages = "1839--1843",

journal = "International Journal of Pharmacognosy and Phytochemical Research",

issn = "0975-4873",

publisher = "Dr. Yashwant Research Labs Pvt. Ltd.",

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T1 - Flavonoids from Leucanthemopsis trifurcatum leaves and their cytotoxic activity

AU - Abdel-Mageed, Wael M.

AU - Attia, Ahmed A.

AU - Al-Saleem, Muneera S.M.

AU - Abdel-Kader, Maged S.

AU - Bolla, Krishna

AU - Ross, Samir A.

PY - 2016/11

Y1 - 2016/11

N2 - A radical scavenging guided phytochemical study on the leaf of Leucanthemopsis trifurcatum afforded twelve flavonoids (1-12). The structures of the isolated compounds were elucidated on the basis of spectroscopic evidences and correlated with known compounds. The cytotoxic activity of the isolated compounds was evaluated against human Hela and MCF-7 cell lines. Compound 1 displays the strongest cytotoxic activity with IC50 values of 10.3 (Hela) and 12.2 µM (MCF-7).

AB - A radical scavenging guided phytochemical study on the leaf of Leucanthemopsis trifurcatum afforded twelve flavonoids (1-12). The structures of the isolated compounds were elucidated on the basis of spectroscopic evidences and correlated with known compounds. The cytotoxic activity of the isolated compounds was evaluated against human Hela and MCF-7 cell lines. Compound 1 displays the strongest cytotoxic activity with IC50 values of 10.3 (Hela) and 12.2 µM (MCF-7).

KW - Chrysanthemum macrocephalum

KW - Cytotoxicity

KW - Flavonoids

KW - Leucanthemopsis trifurcatum

UR - https://www.scopus.com/pages/publications/84995962611

M3 - Article

AN - SCOPUS:84995962611

SN - 0975-4873

VL - 8

SP - 1839

EP - 1843

JO - International Journal of Pharmacognosy and Phytochemical Research

JF - International Journal of Pharmacognosy and Phytochemical Research

IS - 11

ER -

Flavonoids from Leucanthemopsis trifurcatum leaves and their cytotoxic activity

Abstract

Keywords

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