TY - JOUR
T1 - Exploring the multifunctional roles of quantum dots for unlocking the future of biology and medicine
AU - Ali, Muhammad Kashif
AU - Javaid, Saher
AU - Afzal, Haseeb
AU - Zafar, Imran
AU - Fayyaz, Kompal
AU - Ain, Qurat ul
AU - Rather, Mohd Ashraf
AU - Hossain, Md Jamal
AU - Rashid, Summya
AU - Khan, Khalid Ali
AU - Sharma, Rohit
N1 - Publisher Copyright:
© 2023 Elsevier Inc.
PY - 2023/9/1
Y1 - 2023/9/1
N2 - With recent advancements in nanomedicines and their associated research with biological fields, their translation into clinically-applicable products is still below promises. Quantum dots (QDs) have received immense research attention and investment in the four decades since their discovery. We explored the extensive biomedical applications of QDs, viz. Bio-imaging, drug research, drug delivery, immune assays, biosensors, gene therapy, diagnostics, their toxic effects, and bio-compatibility. We unravelled the possibility of using emerging data-driven methodologies (bigdata, artificial intelligence, machine learning, high-throughput experimentation, computational automation) as excellent sources for time, space, and complexity optimization. We also discussed ongoing clinical trials, related challenges, and the technical aspects that should be considered to improve the clinical fate of QDs and promising future research directions.
AB - With recent advancements in nanomedicines and their associated research with biological fields, their translation into clinically-applicable products is still below promises. Quantum dots (QDs) have received immense research attention and investment in the four decades since their discovery. We explored the extensive biomedical applications of QDs, viz. Bio-imaging, drug research, drug delivery, immune assays, biosensors, gene therapy, diagnostics, their toxic effects, and bio-compatibility. We unravelled the possibility of using emerging data-driven methodologies (bigdata, artificial intelligence, machine learning, high-throughput experimentation, computational automation) as excellent sources for time, space, and complexity optimization. We also discussed ongoing clinical trials, related challenges, and the technical aspects that should be considered to improve the clinical fate of QDs and promising future research directions.
KW - Artificial intelligence
KW - Bigdata
KW - Biomedical applications
KW - Drug delivery
KW - High-throughput experimentation
KW - Machine learning
KW - Nanoparticles
KW - Quantum dots
KW - Toxicity
UR - http://www.scopus.com/inward/record.url?scp=85161679393&partnerID=8YFLogxK
U2 - 10.1016/j.envres.2023.116290
DO - 10.1016/j.envres.2023.116290
M3 - Review article
C2 - 37295589
AN - SCOPUS:85161679393
SN - 0013-9351
VL - 232
JO - Environmental Research
JF - Environmental Research
M1 - 116290
ER -