TY - JOUR
T1 - Exploration of New Nickel and Copper(II) Complexes as Potential P53/Caspase 9 Activator in Human Colon Cancer Cell Line
AU - Sahyon, H. A.
AU - Shoair, A. G.F.
AU - Althobaiti, F.
AU - Shanab, M. M.A.H.
AU - Helal, M. A.
AU - Fathy, A. M.
AU - Aldhahrani, A.
N1 - Publisher Copyright:
© 2022, Pleiades Publishing, Ltd.
PY - 2022/10
Y1 - 2022/10
N2 - Abstract: The two new complexes, namely [NiU2(H2O)2]SO4, (NiU) and [CuU2(H2O)2]SO4, (CuU) [U = 5,6-diamino-1,3-dimethyl-2,4(1H,3H)-pyrimidinedione monohydrate] were synthesized and characterized by elemental analysis, physicochemical, spectroscopic, (UV-visible, IR, ESI-MS, and XRD), thermal analysis and cyclic voltametric techniques. As showed in the data obtained, an octahedral geometry has been assigned for the two complexes. The data proved that the new complexes NiU and CuU have anticancer activities against colon cancer (HCT-116), epithelioid carcinoma (HeLa), and prostate adenocarcinoma (PC3) human cancer cell lines. The apoptotic pathway for both NiU and CuU complexes was via p53 elevation, which can arrest the cell cycle and activate the release of cytochrome c. The HCT-116 cells were treated with either NiU or CuU complexes had increased the production of caspase-9, which can activate the production of caspase-3 that degrades all the proteins in the cell, leading to apoptotic cell death. Consequently, the two complexes have promising anticancer activities.
AB - Abstract: The two new complexes, namely [NiU2(H2O)2]SO4, (NiU) and [CuU2(H2O)2]SO4, (CuU) [U = 5,6-diamino-1,3-dimethyl-2,4(1H,3H)-pyrimidinedione monohydrate] were synthesized and characterized by elemental analysis, physicochemical, spectroscopic, (UV-visible, IR, ESI-MS, and XRD), thermal analysis and cyclic voltametric techniques. As showed in the data obtained, an octahedral geometry has been assigned for the two complexes. The data proved that the new complexes NiU and CuU have anticancer activities against colon cancer (HCT-116), epithelioid carcinoma (HeLa), and prostate adenocarcinoma (PC3) human cancer cell lines. The apoptotic pathway for both NiU and CuU complexes was via p53 elevation, which can arrest the cell cycle and activate the release of cytochrome c. The HCT-116 cells were treated with either NiU or CuU complexes had increased the production of caspase-9, which can activate the production of caspase-3 that degrades all the proteins in the cell, leading to apoptotic cell death. Consequently, the two complexes have promising anticancer activities.
KW - caspase-9
KW - copper(II) complexes
KW - cytochrome C
KW - DNA binding
KW - nickel(II)
KW - P53
UR - http://www.scopus.com/inward/record.url?scp=85141389964&partnerID=8YFLogxK
U2 - 10.1134/S1070363222100206
DO - 10.1134/S1070363222100206
M3 - Article
AN - SCOPUS:85141389964
SN - 1070-3632
VL - 92
SP - 2058
EP - 2069
JO - Russian Journal of General Chemistry
JF - Russian Journal of General Chemistry
IS - 10
ER -
