TY - JOUR
T1 - Epigallocatechin-3-Gallate Therapeutic Potential in Cancer
T2 - Mechanism of Action and Clinical Implications
AU - Kciuk, Mateusz
AU - Alam, Manzar
AU - Ali, Nemat
AU - Rashid, Summya
AU - Głowacka, Pola
AU - Sundaraj, Rajamanikandan
AU - Celik, Ismail
AU - Yahya, Esam Bashir
AU - Dubey, Amit
AU - Zerroug, Enfale
AU - Kontek, Renata
N1 - Publisher Copyright:
© 2023 by the authors.
PY - 2023/7
Y1 - 2023/7
N2 - Cellular signaling pathways involved in the maintenance of the equilibrium between cell proliferation and apoptosis have emerged as rational targets that can be exploited in the prevention and treatment of cancer. Epigallocatechin-3-gallate (EGCG) is the most abundant phenolic compound found in green tea. It has been shown to regulate multiple crucial cellular signaling pathways, including those mediated by EGFR, JAK-STAT, MAPKs, NF-κB, PI3K-AKT-mTOR, and others. Deregulation of the abovementioned pathways is involved in the pathophysiology of cancer. It has been demonstrated that EGCG may exert anti-proliferative, anti-inflammatory, and apoptosis-inducing effects or induce epigenetic changes. Furthermore, preclinical and clinical studies suggest that EGCG may be used in the treatment of numerous disorders, including cancer. This review aims to summarize the existing knowledge regarding the biological properties of EGCG, especially in the context of cancer treatment and prophylaxis.
AB - Cellular signaling pathways involved in the maintenance of the equilibrium between cell proliferation and apoptosis have emerged as rational targets that can be exploited in the prevention and treatment of cancer. Epigallocatechin-3-gallate (EGCG) is the most abundant phenolic compound found in green tea. It has been shown to regulate multiple crucial cellular signaling pathways, including those mediated by EGFR, JAK-STAT, MAPKs, NF-κB, PI3K-AKT-mTOR, and others. Deregulation of the abovementioned pathways is involved in the pathophysiology of cancer. It has been demonstrated that EGCG may exert anti-proliferative, anti-inflammatory, and apoptosis-inducing effects or induce epigenetic changes. Furthermore, preclinical and clinical studies suggest that EGCG may be used in the treatment of numerous disorders, including cancer. This review aims to summarize the existing knowledge regarding the biological properties of EGCG, especially in the context of cancer treatment and prophylaxis.
KW - bioavailability
KW - clinical trials
KW - epigallocatechin gallate
KW - signaling pathways
UR - http://www.scopus.com/inward/record.url?scp=85164906914&partnerID=8YFLogxK
U2 - 10.3390/molecules28135246
DO - 10.3390/molecules28135246
M3 - Review article
AN - SCOPUS:85164906914
SN - 1420-3049
VL - 28
JO - Molecules
JF - Molecules
IS - 13
M1 - 5246
ER -
