Efficacy of Subgingivally Delivered Satranidazole in the Treatment of Type 2 Diabetes Subjects with Chronic Periodontitis: A Randomized Controlled Clinical Trial

N. Priyanka; Nitish Kalra; Shahab Saquib; Shahabe Saquib; Nikhil Malgaonkar; Malgaonkar Nikhil; Bassel Tarakji; Jadhav Varsha; Davangere Umashree; A. R. Pradeep

Efficacy of Subgingivally Delivered Satranidazole in the Treatment of Type 2 Diabetes Subjects with Chronic Periodontitis: A Randomized Controlled Clinical Trial

N. Priyanka, Nitish Kalra, Shahab Saquib, Shahabe Saquib, Nikhil Malgaonkar, Malgaonkar Nikhil, Bassel Tarakji, Jadhav Varsha, Davangere Umashree, A. R. Pradeep

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Research output: Contribution to journal › Article › peer-review

12 Scopus citations

Abstract

BACKGROUND: The present clinical trial was designed to investigate the effectiveness of subgingivally delivered satranidazole (SZ) gel as an adjunct to scaling and root planing (SRP) in the treatment of chronic periodontitis.

METHODS: Sixty-four subjects with probing depth (PD) ≥ 5 mm and who were diagnosed with type 2 diabetes were selected. Thirty-two subjects each were randomly assigned to SRP + placebo (Group 1) and SRP + SZ (Group 2). The clinical outcomes evaluated were plaque index (PI), gingival index (GI), clinical attachment level (CAL) and PD at baseline, 1 month, 3-months and 6 months.

RESULTS: At 6 months, Group 2 had greater mean reduction (4.73 mm) in PD as compared to Group 1 (2.09 mm; p < 0.05) and also a greater mean CAL gain (3.92 mm versus 1.64 mm; p < 0.05).

CONCLUSION: The use of 3% SZ gel, when used as an adjunct to non-surgical periodontal therapy in subjects with periodontitis, achieves significantly better clinical results than initial periodontal treatment alone.

Original language	English
Pages (from-to)	42-48
Number of pages	7
Journal	Journal of the International Academy of Periodontology
Volume	17
Issue number	2
State	Published - 1 Apr 2015
Externally published	Yes

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Priyanka, N., Kalra, N., Saquib, S., Saquib, S., Malgaonkar, N., Nikhil, M., Tarakji, B., Varsha, J., Umashree, D., & Pradeep, A. R. (2015). Efficacy of Subgingivally Delivered Satranidazole in the Treatment of Type 2 Diabetes Subjects with Chronic Periodontitis: A Randomized Controlled Clinical Trial. Journal of the International Academy of Periodontology, 17(2), 42-48.

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title = "Efficacy of Subgingivally Delivered Satranidazole in the Treatment of Type 2 Diabetes Subjects with Chronic Periodontitis: A Randomized Controlled Clinical Trial",

abstract = "BACKGROUND: The present clinical trial was designed to investigate the effectiveness of subgingivally delivered satranidazole (SZ) gel as an adjunct to scaling and root planing (SRP) in the treatment of chronic periodontitis.METHODS: Sixty-four subjects with probing depth (PD) ≥ 5 mm and who were diagnosed with type 2 diabetes were selected. Thirty-two subjects each were randomly assigned to SRP + placebo (Group 1) and SRP + SZ (Group 2). The clinical outcomes evaluated were plaque index (PI), gingival index (GI), clinical attachment level (CAL) and PD at baseline, 1 month, 3-months and 6 months.RESULTS: At 6 months, Group 2 had greater mean reduction (4.73 mm) in PD as compared to Group 1 (2.09 mm; p < 0.05) and also a greater mean CAL gain (3.92 mm versus 1.64 mm; p < 0.05).CONCLUSION: The use of 3\% SZ gel, when used as an adjunct to non-surgical periodontal therapy in subjects with periodontitis, achieves significantly better clinical results than initial periodontal treatment alone.",

author = "N. Priyanka and Nitish Kalra and Shahab Saquib and Shahabe Saquib and Nikhil Malgaonkar and Malgaonkar Nikhil and Bassel Tarakji and Jadhav Varsha and Davangere Umashree and Pradeep, \{A. R.\}",

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Priyanka, N, Kalra, N, Saquib, S, Saquib, S, Malgaonkar, N, Nikhil, M, Tarakji, B, Varsha, J, Umashree, D & Pradeep, AR 2015, 'Efficacy of Subgingivally Delivered Satranidazole in the Treatment of Type 2 Diabetes Subjects with Chronic Periodontitis: A Randomized Controlled Clinical Trial', Journal of the International Academy of Periodontology, vol. 17, no. 2, pp. 42-48.

Efficacy of Subgingivally Delivered Satranidazole in the Treatment of Type 2 Diabetes Subjects with Chronic Periodontitis: A Randomized Controlled Clinical Trial. / Priyanka, N.; Kalra, Nitish; Saquib, Shahab et al.
In: Journal of the International Academy of Periodontology, Vol. 17, No. 2, 01.04.2015, p. 42-48.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Efficacy of Subgingivally Delivered Satranidazole in the Treatment of Type 2 Diabetes Subjects with Chronic Periodontitis

T2 - A Randomized Controlled Clinical Trial

AU - Priyanka, N.

AU - Kalra, Nitish

AU - Saquib, Shahab

AU - Saquib, Shahabe

AU - Malgaonkar, Nikhil

AU - Nikhil, Malgaonkar

AU - Tarakji, Bassel

AU - Varsha, Jadhav

AU - Umashree, Davangere

AU - Pradeep, A. R.

PY - 2015/4/1

Y1 - 2015/4/1

N2 - BACKGROUND: The present clinical trial was designed to investigate the effectiveness of subgingivally delivered satranidazole (SZ) gel as an adjunct to scaling and root planing (SRP) in the treatment of chronic periodontitis.METHODS: Sixty-four subjects with probing depth (PD) ≥ 5 mm and who were diagnosed with type 2 diabetes were selected. Thirty-two subjects each were randomly assigned to SRP + placebo (Group 1) and SRP + SZ (Group 2). The clinical outcomes evaluated were plaque index (PI), gingival index (GI), clinical attachment level (CAL) and PD at baseline, 1 month, 3-months and 6 months.RESULTS: At 6 months, Group 2 had greater mean reduction (4.73 mm) in PD as compared to Group 1 (2.09 mm; p < 0.05) and also a greater mean CAL gain (3.92 mm versus 1.64 mm; p < 0.05).CONCLUSION: The use of 3% SZ gel, when used as an adjunct to non-surgical periodontal therapy in subjects with periodontitis, achieves significantly better clinical results than initial periodontal treatment alone.

AB - BACKGROUND: The present clinical trial was designed to investigate the effectiveness of subgingivally delivered satranidazole (SZ) gel as an adjunct to scaling and root planing (SRP) in the treatment of chronic periodontitis.METHODS: Sixty-four subjects with probing depth (PD) ≥ 5 mm and who were diagnosed with type 2 diabetes were selected. Thirty-two subjects each were randomly assigned to SRP + placebo (Group 1) and SRP + SZ (Group 2). The clinical outcomes evaluated were plaque index (PI), gingival index (GI), clinical attachment level (CAL) and PD at baseline, 1 month, 3-months and 6 months.RESULTS: At 6 months, Group 2 had greater mean reduction (4.73 mm) in PD as compared to Group 1 (2.09 mm; p < 0.05) and also a greater mean CAL gain (3.92 mm versus 1.64 mm; p < 0.05).CONCLUSION: The use of 3% SZ gel, when used as an adjunct to non-surgical periodontal therapy in subjects with periodontitis, achieves significantly better clinical results than initial periodontal treatment alone.

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SN - 1466-2094

VL - 17

SP - 42

EP - 48

JO - Journal of the International Academy of Periodontology

JF - Journal of the International Academy of Periodontology

IS - 2

ER -

Efficacy of Subgingivally Delivered Satranidazole in the Treatment of Type 2 Diabetes Subjects with Chronic Periodontitis: A Randomized Controlled Clinical Trial

Abstract

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