DuCLOX-2/5 inhibition: a promising target for cancer chemoprevention

Swetlana Gautam; Subhadeep Roy; Mohd Nazam Ansari; Abdulaziz S. Saeedan; Shubhini A. Saraf; Gaurav Kaithwas

doi:10.1007/s12282-016-0723-2

DuCLOX-2/5 inhibition: a promising target for cancer chemoprevention

Swetlana Gautam
, Subhadeep Roy
, Mohd Nazam Ansari
, Abdulaziz S. Saeedan
, Shubhini A. Saraf
, Gaurav Kaithwas

Pharmacology

Babasaheb Bhimrao Ambedkar University

Research output: Contribution to journal › Review article › peer-review

36 Scopus citations

Abstract

Cancer is a leading cause of death and major health concern worldwide. The animal and human studies support the presumption that inflammation directs the cancer initiation and progression. Cyclooxygenase-2 (COX-2) and 5-lipoxygenase (5-LOX) are the key players in the inflammatory cascade contributing towards the angiogenesis, tumor cell invasiveness, and disruption in the pathways of cellular proliferation/apoptosis. Contemporary studies have particularized a promising role of COX-2 and 5-LOX inhibitors in cancer chemoprevention. The present review is a pursuit to define implications of dual COX-2 and 5-LOX (DuCLOX-2/5) inhibition on various aspects of cancer augmentation and chemoprevention.

Original language	English
Pages (from-to)	180-190
Number of pages	11
Journal	Breast Cancer
Volume	24
Issue number	2
DOIs	https://doi.org/10.1007/s12282-016-0723-2
State	Published - 1 Mar 2017

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Angiogenesis
Apoptosis
Cyclooxygenase
Lipoxygenase
NSAIDs
Proliferation

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10.1007/s12282-016-0723-2

Cite this

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title = "DuCLOX-2/5 inhibition: a promising target for cancer chemoprevention",

abstract = "Cancer is a leading cause of death and major health concern worldwide. The animal and human studies support the presumption that inflammation directs the cancer initiation and progression. Cyclooxygenase-2 (COX-2) and 5-lipoxygenase (5-LOX) are the key players in the inflammatory cascade contributing towards the angiogenesis, tumor cell invasiveness, and disruption in the pathways of cellular proliferation/apoptosis. Contemporary studies have particularized a promising role of COX-2 and 5-LOX inhibitors in cancer chemoprevention. The present review is a pursuit to define implications of dual COX-2 and 5-LOX (DuCLOX-2/5) inhibition on various aspects of cancer augmentation and chemoprevention.",

keywords = "Angiogenesis, Apoptosis, Cyclooxygenase, Lipoxygenase, NSAIDs, Proliferation",

author = "Swetlana Gautam and Subhadeep Roy and Ansari, \{Mohd Nazam\} and Saeedan, \{Abdulaziz S.\} and Saraf, \{Shubhini A.\} and Gaurav Kaithwas",

note = "Publisher Copyright: {\textcopyright} 2016, The Japanese Breast Cancer Society.",

year = "2017",

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doi = "10.1007/s12282-016-0723-2",

language = "English",

volume = "24",

pages = "180--190",

journal = "Breast Cancer",

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}

TY - JOUR

T1 - DuCLOX-2/5 inhibition

T2 - a promising target for cancer chemoprevention

AU - Gautam, Swetlana

AU - Roy, Subhadeep

AU - Ansari, Mohd Nazam

AU - Saeedan, Abdulaziz S.

AU - Saraf, Shubhini A.

AU - Kaithwas, Gaurav

PY - 2017/3/1

Y1 - 2017/3/1

N2 - Cancer is a leading cause of death and major health concern worldwide. The animal and human studies support the presumption that inflammation directs the cancer initiation and progression. Cyclooxygenase-2 (COX-2) and 5-lipoxygenase (5-LOX) are the key players in the inflammatory cascade contributing towards the angiogenesis, tumor cell invasiveness, and disruption in the pathways of cellular proliferation/apoptosis. Contemporary studies have particularized a promising role of COX-2 and 5-LOX inhibitors in cancer chemoprevention. The present review is a pursuit to define implications of dual COX-2 and 5-LOX (DuCLOX-2/5) inhibition on various aspects of cancer augmentation and chemoprevention.

AB - Cancer is a leading cause of death and major health concern worldwide. The animal and human studies support the presumption that inflammation directs the cancer initiation and progression. Cyclooxygenase-2 (COX-2) and 5-lipoxygenase (5-LOX) are the key players in the inflammatory cascade contributing towards the angiogenesis, tumor cell invasiveness, and disruption in the pathways of cellular proliferation/apoptosis. Contemporary studies have particularized a promising role of COX-2 and 5-LOX inhibitors in cancer chemoprevention. The present review is a pursuit to define implications of dual COX-2 and 5-LOX (DuCLOX-2/5) inhibition on various aspects of cancer augmentation and chemoprevention.

KW - Angiogenesis

KW - Apoptosis

KW - Cyclooxygenase

KW - Lipoxygenase

KW - NSAIDs

KW - Proliferation

UR - https://www.scopus.com/pages/publications/84983432875

U2 - 10.1007/s12282-016-0723-2

DO - 10.1007/s12282-016-0723-2

M3 - Review article

C2 - 27558792

AN - SCOPUS:84983432875

SN - 1340-6868

VL - 24

SP - 180

EP - 190

JO - Breast Cancer

JF - Breast Cancer

IS - 2

ER -

DuCLOX-2/5 inhibition: a promising target for cancer chemoprevention

Abstract

UN SDGs

Keywords

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