DuCLOX-2/5 inhibition: a promising target for cancer chemoprevention

Swetlana Gautam; Subhadeep Roy; Mohd Nazam Ansari; Abdulaziz S. Saeedan; Shubhini A. Saraf; Gaurav Kaithwas

doi:10.1007/s12282-016-0723-2

DuCLOX-2/5 inhibition: a promising target for cancer chemoprevention

Swetlana Gautam, Subhadeep Roy, Mohd Nazam Ansari, Abdulaziz S. Saeedan, Shubhini A. Saraf, Gaurav Kaithwas

Pharmacology

Babasaheb Bhimrao Ambedkar University

Research output: Contribution to journal › Review article › peer-review

32 Scopus citations

Abstract

Cancer is a leading cause of death and major health concern worldwide. The animal and human studies support the presumption that inflammation directs the cancer initiation and progression. Cyclooxygenase-2 (COX-2) and 5-lipoxygenase (5-LOX) are the key players in the inflammatory cascade contributing towards the angiogenesis, tumor cell invasiveness, and disruption in the pathways of cellular proliferation/apoptosis. Contemporary studies have particularized a promising role of COX-2 and 5-LOX inhibitors in cancer chemoprevention. The present review is a pursuit to define implications of dual COX-2 and 5-LOX (DuCLOX-2/5) inhibition on various aspects of cancer augmentation and chemoprevention.

Original language	English
Pages (from-to)	180-190
Number of pages	11
Journal	Breast Cancer
Volume	24
Issue number	2
DOIs	https://doi.org/10.1007/s12282-016-0723-2
State	Published - 1 Mar 2017

Keywords

Angiogenesis
Apoptosis
Cyclooxygenase
Lipoxygenase
NSAIDs
Proliferation

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1007/s12282-016-0723-2

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title = "DuCLOX-2/5 inhibition: a promising target for cancer chemoprevention",

abstract = "Cancer is a leading cause of death and major health concern worldwide. The animal and human studies support the presumption that inflammation directs the cancer initiation and progression. Cyclooxygenase-2 (COX-2) and 5-lipoxygenase (5-LOX) are the key players in the inflammatory cascade contributing towards the angiogenesis, tumor cell invasiveness, and disruption in the pathways of cellular proliferation/apoptosis. Contemporary studies have particularized a promising role of COX-2 and 5-LOX inhibitors in cancer chemoprevention. The present review is a pursuit to define implications of dual COX-2 and 5-LOX (DuCLOX-2/5) inhibition on various aspects of cancer augmentation and chemoprevention.",

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doi = "10.1007/s12282-016-0723-2",

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T1 - DuCLOX-2/5 inhibition

T2 - a promising target for cancer chemoprevention

AU - Gautam, Swetlana

AU - Roy, Subhadeep

AU - Ansari, Mohd Nazam

AU - Saeedan, Abdulaziz S.

AU - Saraf, Shubhini A.

AU - Kaithwas, Gaurav

PY - 2017/3/1

Y1 - 2017/3/1

N2 - Cancer is a leading cause of death and major health concern worldwide. The animal and human studies support the presumption that inflammation directs the cancer initiation and progression. Cyclooxygenase-2 (COX-2) and 5-lipoxygenase (5-LOX) are the key players in the inflammatory cascade contributing towards the angiogenesis, tumor cell invasiveness, and disruption in the pathways of cellular proliferation/apoptosis. Contemporary studies have particularized a promising role of COX-2 and 5-LOX inhibitors in cancer chemoprevention. The present review is a pursuit to define implications of dual COX-2 and 5-LOX (DuCLOX-2/5) inhibition on various aspects of cancer augmentation and chemoprevention.

AB - Cancer is a leading cause of death and major health concern worldwide. The animal and human studies support the presumption that inflammation directs the cancer initiation and progression. Cyclooxygenase-2 (COX-2) and 5-lipoxygenase (5-LOX) are the key players in the inflammatory cascade contributing towards the angiogenesis, tumor cell invasiveness, and disruption in the pathways of cellular proliferation/apoptosis. Contemporary studies have particularized a promising role of COX-2 and 5-LOX inhibitors in cancer chemoprevention. The present review is a pursuit to define implications of dual COX-2 and 5-LOX (DuCLOX-2/5) inhibition on various aspects of cancer augmentation and chemoprevention.

KW - Angiogenesis

KW - Apoptosis

KW - Cyclooxygenase

KW - Lipoxygenase

KW - NSAIDs

KW - Proliferation

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DuCLOX-2/5 inhibition: a promising target for cancer chemoprevention

Abstract

Keywords

UN SDGs

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