Design, synthesis, molecular docking, and in vitro studies of 2-mercaptoquinazolin-4(3H)-ones as potential anti-breast cancer agents

Medicine and Dentistry

• Carcinogen 100%
• Protein P53 66%
• Protein Tyrosine Kinase 33%
• Flow Cytometry 33%
• DNA Fragmentation 33%
• Gel Electrophoresis 33%
• Gene Expression 33%
• Ispinesib 33%
• Invasive Procedure 33%
• Idelalisib 33%
• Radiation Therapy 33%
• MTT Assay 33%
• Lipocortin 5 33%
• Targeted Therapy 33%
• Antineoplastic Activity 33%
• Downregulation 33%
• Anticancer Drug 33%
• Quinazolinone Derivative 33%
• Enzyme Inhibition Assay 33%
• Antiapoptotic 33%
• Real Time Polymerase Chain Reaction 33%

Biochemistry, Genetics and Molecular Biology

• In Vitro Study 100%
• P53 50%
• Gel Electrophoresis 25%
• Downregulation 25%
• Receptor Tyrosine Kinase 25%
• DNA Fragmentation 25%
• Blebbing 25%
• Lipocortin 25%
• Real-Time Polymerase Chain Reaction 25%
• Flow Cytometry 25%
• Gene Expression 25%
• Antineoplastic Activity 25%
• MTT Assay 25%
• Cancer Cell 25%
• Solution and Solubility 25%
• Enzyme Inhibition 25%

Pharmacology, Toxicology and Pharmaceutical Science

• Carcinogen 100%
• Protein Tyrosine Kinase 33%
• Enzyme Inhibition 33%
• Flow Cytometry 33%
• Idelalisib 33%
• Chemotherapy 33%
• Lipocortin 5 33%
• Ispinesib 33%
• Quinazolinone Derivative 33%
• Antiapoptotic 33%
• Gel Electrophoresis 33%