Design, statistical optimization, and characterization of Esculin-loaded transliposome nanogel for topical delivery: In-vitro, ex vivo study and dermatokinetic evaluation

Abdullah S. Alshetaili

doi:10.1016/j.jksus.2024.103166

Design, statistical optimization, and characterization of Esculin-loaded transliposome nanogel for topical delivery: In-vitro, ex vivo study and dermatokinetic evaluation

Abdullah S. Alshetaili

Pharmaceutics

Research output: Contribution to journal › Article › peer-review

6 Scopus citations

Abstract

The purpose of this study was to prepare and optimise an Esculin-loaded transliposome (ECL-TL) for the dermal administration of ECL for skin cancer treatment. The ECL-TL formulation effectively produced closed lamellar vesicles with in-vitro drug release of 81.28 ± 2.82 % and ex-vivo penetration studies showed that had a 2.2-part intensified permeability compared to the conventional preparation. The CLSM data of skin visibly displayed intense permeation of ECL-TL formulated with rhodamine B, equating to the rhodamine B hydroalcoholic solution. The dermatokinetic study suggested that TLs enhance the permeability of the delivery system when topically applied. According to the data, the developed ECL-TL could be an effective drug nano-carrier for the dermal delivery of ECL in treating skin cancer.

Original language	English
Article number	103166
Journal	Journal of King Saud University - Science
Volume	36
Issue number	5
DOIs	https://doi.org/10.1016/j.jksus.2024.103166
State	Published - May 2024

Keywords

Dermal
Dermatokinetic
Esculin
Gel
Transliposomes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.jksus.2024.103166

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title = "Design, statistical optimization, and characterization of Esculin-loaded transliposome nanogel for topical delivery: In-vitro, ex vivo study and dermatokinetic evaluation",

abstract = "The purpose of this study was to prepare and optimise an Esculin-loaded transliposome (ECL-TL) for the dermal administration of ECL for skin cancer treatment. The ECL-TL formulation effectively produced closed lamellar vesicles with in-vitro drug release of 81.28 ± 2.82 \% and ex-vivo penetration studies showed that had a 2.2-part intensified permeability compared to the conventional preparation. The CLSM data of skin visibly displayed intense permeation of ECL-TL formulated with rhodamine B, equating to the rhodamine B hydroalcoholic solution. The dermatokinetic study suggested that TLs enhance the permeability of the delivery system when topically applied. According to the data, the developed ECL-TL could be an effective drug nano-carrier for the dermal delivery of ECL in treating skin cancer.",

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N2 - The purpose of this study was to prepare and optimise an Esculin-loaded transliposome (ECL-TL) for the dermal administration of ECL for skin cancer treatment. The ECL-TL formulation effectively produced closed lamellar vesicles with in-vitro drug release of 81.28 ± 2.82 % and ex-vivo penetration studies showed that had a 2.2-part intensified permeability compared to the conventional preparation. The CLSM data of skin visibly displayed intense permeation of ECL-TL formulated with rhodamine B, equating to the rhodamine B hydroalcoholic solution. The dermatokinetic study suggested that TLs enhance the permeability of the delivery system when topically applied. According to the data, the developed ECL-TL could be an effective drug nano-carrier for the dermal delivery of ECL in treating skin cancer.

AB - The purpose of this study was to prepare and optimise an Esculin-loaded transliposome (ECL-TL) for the dermal administration of ECL for skin cancer treatment. The ECL-TL formulation effectively produced closed lamellar vesicles with in-vitro drug release of 81.28 ± 2.82 % and ex-vivo penetration studies showed that had a 2.2-part intensified permeability compared to the conventional preparation. The CLSM data of skin visibly displayed intense permeation of ECL-TL formulated with rhodamine B, equating to the rhodamine B hydroalcoholic solution. The dermatokinetic study suggested that TLs enhance the permeability of the delivery system when topically applied. According to the data, the developed ECL-TL could be an effective drug nano-carrier for the dermal delivery of ECL in treating skin cancer.

KW - Dermal

KW - Dermatokinetic

KW - Esculin

KW - Gel

KW - Transliposomes

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JO - Journal of King Saud University - Science

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ER -

Design, statistical optimization, and characterization of Esculin-loaded transliposome nanogel for topical delivery: In-vitro, ex vivo study and dermatokinetic evaluation

Abstract

Keywords

UN SDGs

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