Cytotoxicity evaluation of environmentally friendly synthesis Copper/Zinc bimetallic nanoparticles on MCF-7 cancer cells

Firoozeh Abolhasani Zadeh, Dmitry Olegovich Bokov, Omar Dheyauldeen Salahdin, Walid Kamal Abdelbasset, Mohammed Abed Jawad, Mustafa M. Kadhim, Maytham T. Qasim, Hamzah H. Kzar, Moaed E. Al-Gazally, Yasser Fakri Mustafa, M. Khatami

Research output: Contribution to journalArticlepeer-review

67 Scopus citations

Abstract

Bimetallic nanoparticles offer unique chemical, physical and optical properties that are not available for monometallic nanoparticles. Bimetallic nanoparticles play a major role in various therapeutic, industrial and energy fields. Recently, nanoparticles of Copper/Zinc bimetallic nanoparticles have attracted attention in various fields, especially medicine. In this study, bimetallic CuO/ZnO nanostructures were biosynthesized using plant extracts. The plant-mediated synthesis nanoparticles were characterized by Transmission electron microscopy (TEM), X-ray diffraction analysis (XRD), Field Emission Scanning Electron Microscopy (FESEM) and Energy-Dispersive Spectroscopy (EDAX). The cytotoxicity of plant-mediated synthesis bimetallic nanoparticles and the synergistic effects of these nanoparticles in combination with the anticancer drug doxorubicin on MCF-7 cancer cells were evaluated by MTT assay.

Original languageEnglish
Pages (from-to)441-447
Number of pages7
JournalRendiconti Lincei
Volume33
Issue number2
DOIs
StatePublished - Jun 2022

Keywords

  • Copper/Zinc bimetallic nanoparticle
  • Cytotoxicity
  • Environmentally friendly
  • MCF-7 cancer cells
  • MTT assay

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