Copper(ii) complexes supported by modified azo-based ligands: Nucleic acid binding and molecular docking studies

Mamta Tripathi; Ashish Kumar Asatkar; Stalin Antony; Mrinal Kanti Dash; Gourisankar Roymahapatra; Rama Pande; Avijit Sarkar; Fahad M. Aldakheel; Abdulkarim S. Binshaya; Nahed S. Alharthi; Ahmed L. Alaofi; Mohammed S. Alqahtani; Rabbani Syed

doi:10.1515/chem-2022-0164

Copper(ii) complexes supported by modified azo-based ligands: Nucleic acid binding and molecular docking studies

Mamta Tripathi, Ashish Kumar Asatkar, Stalin Antony, Mrinal Kanti Dash, Gourisankar Roymahapatra, Rama Pande, Avijit Sarkar, Fahad M. Aldakheel, Abdulkarim S. Binshaya, Nahed S. Alharthi, Ahmed L. Alaofi, Mohammed S. Alqahtani, Rabbani Syed

Medical Laboratory Sciences

Research output: Contribution to journal › Article › peer-review

4 Scopus citations

Abstract

Two new copper(ii) complexes [CuL1] (1) and [CuL2] (2) derived from azo-based ligands 2-hydroxy-5-p-tolylazo-benzaldehyde (HL1) and 1-(2-hydroxy-5-p-tolylazo-phenyl)-ethan-one (HL2) were synthesized. These two ligands and their metal complexes were characterized by elemental analysis, nuclear magnetic resonance (1H and 13C), infrared, and UV/Vis spectroscopic techniques. Spectroscopy and other theoretical studies reveal the geometry of copper complexes, and their binding affinity towards nucleic acids are major groove binding.

Original language	English
Pages (from-to)	505-516
Number of pages	12
Journal	Open Chemistry
Volume	20
Issue number	1
DOIs	https://doi.org/10.1515/chem-2022-0164
State	Published - 1 Jan 2022

Keywords

azo
copper(ii) complexes
ct-DNA
DFT
molecular docking
t-RNA

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Tripathi, M., Asatkar, A. K., Antony, S., Dash, M. K., Roymahapatra, G., Pande, R., Sarkar, A., Aldakheel, F. M., Binshaya, A. S., Alharthi, N. S., Alaofi, A. L., Alqahtani, M. S., & Syed, R. (2022). Copper(ii) complexes supported by modified azo-based ligands: Nucleic acid binding and molecular docking studies. Open Chemistry, 20(1), 505-516. https://doi.org/10.1515/chem-2022-0164

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title = "Copper(ii) complexes supported by modified azo-based ligands: Nucleic acid binding and molecular docking studies",

abstract = "Two new copper(ii) complexes [CuL1] (1) and [CuL2] (2) derived from azo-based ligands 2-hydroxy-5-p-tolylazo-benzaldehyde (HL1) and 1-(2-hydroxy-5-p-tolylazo-phenyl)-ethan-one (HL2) were synthesized. These two ligands and their metal complexes were characterized by elemental analysis, nuclear magnetic resonance (1H and 13C), infrared, and UV/Vis spectroscopic techniques. Spectroscopy and other theoretical studies reveal the geometry of copper complexes, and their binding affinity towards nucleic acids are major groove binding.",

keywords = "azo, copper(ii) complexes, ct-DNA, DFT, molecular docking, t-RNA",

author = "Mamta Tripathi and Asatkar, \{Ashish Kumar\} and Stalin Antony and Dash, \{Mrinal Kanti\} and Gourisankar Roymahapatra and Rama Pande and Avijit Sarkar and Aldakheel, \{Fahad M.\} and Binshaya, \{Abdulkarim S.\} and Alharthi, \{Nahed S.\} and Alaofi, \{Ahmed L.\} and Alqahtani, \{Mohammed S.\} and Rabbani Syed",

note = "Publisher Copyright: {\textcopyright} 2022 Mamta Tripathi et al., published by De Gruyter.",

year = "2022",

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doi = "10.1515/chem-2022-0164",

language = "English",

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T1 - Copper(ii) complexes supported by modified azo-based ligands

T2 - Nucleic acid binding and molecular docking studies

AU - Tripathi, Mamta

AU - Asatkar, Ashish Kumar

AU - Antony, Stalin

AU - Dash, Mrinal Kanti

AU - Roymahapatra, Gourisankar

AU - Pande, Rama

AU - Sarkar, Avijit

AU - Aldakheel, Fahad M.

AU - Binshaya, Abdulkarim S.

AU - Alharthi, Nahed S.

AU - Alaofi, Ahmed L.

AU - Alqahtani, Mohammed S.

AU - Syed, Rabbani

PY - 2022/1/1

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AB - Two new copper(ii) complexes [CuL1] (1) and [CuL2] (2) derived from azo-based ligands 2-hydroxy-5-p-tolylazo-benzaldehyde (HL1) and 1-(2-hydroxy-5-p-tolylazo-phenyl)-ethan-one (HL2) were synthesized. These two ligands and their metal complexes were characterized by elemental analysis, nuclear magnetic resonance (1H and 13C), infrared, and UV/Vis spectroscopic techniques. Spectroscopy and other theoretical studies reveal the geometry of copper complexes, and their binding affinity towards nucleic acids are major groove binding.

KW - azo

KW - copper(ii) complexes

KW - ct-DNA

KW - DFT

KW - molecular docking

KW - t-RNA

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DO - 10.1515/chem-2022-0164

M3 - Article

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VL - 20

SP - 505

EP - 516

JO - Open Chemistry

JF - Open Chemistry

IS - 1

ER -

Copper(ii) complexes supported by modified azo-based ligands: Nucleic acid binding and molecular docking studies

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Keywords

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