Copper(ii) complexes supported by modified azo-based ligands: Nucleic acid binding and molecular docking studies

Mamta Tripathi; Ashish Kumar Asatkar; Stalin Antony; Mrinal Kanti Dash; Gourisankar Roymahapatra; Rama Pande; Avijit Sarkar; Fahad M. Aldakheel; Abdulkarim S. Binshaya; Nahed S. Alharthi; Ahmed L. Alaofi; Mohammed S. Alqahtani; Rabbani Syed

doi:10.1515/chem-2022-0164

Copper(ii) complexes supported by modified azo-based ligands: Nucleic acid binding and molecular docking studies

Mamta Tripathi
, Ashish Kumar Asatkar
, Stalin Antony
, Mrinal Kanti Dash
, Gourisankar Roymahapatra
, Rama Pande
, Avijit Sarkar
, Fahad M. Aldakheel
, Abdulkarim S. Binshaya
, Nahed S. Alharthi
, Ahmed L. Alaofi
, Mohammed S. Alqahtani
, Rabbani Syed

Medical Laboratory Sciences

Research output: Contribution to journal › Article › peer-review

5 Scopus citations

Abstract

Two new copper(ii) complexes [CuL1] (1) and [CuL2] (2) derived from azo-based ligands 2-hydroxy-5-p-tolylazo-benzaldehyde (HL1) and 1-(2-hydroxy-5-p-tolylazo-phenyl)-ethan-one (HL2) were synthesized. These two ligands and their metal complexes were characterized by elemental analysis, nuclear magnetic resonance (1H and 13C), infrared, and UV/Vis spectroscopic techniques. Spectroscopy and other theoretical studies reveal the geometry of copper complexes, and their binding affinity towards nucleic acids are major groove binding.

Original language	English
Pages (from-to)	505-516
Number of pages	12
Journal	Open Chemistry
Volume	20
Issue number	1
DOIs	https://doi.org/10.1515/chem-2022-0164
State	Published - 1 Jan 2022

Keywords

azo
copper(ii) complexes
ct-DNA
DFT
molecular docking
t-RNA

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10.1515/chem-2022-0164

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Tripathi, M., Asatkar, A. K., Antony, S., Dash, M. K., Roymahapatra, G., Pande, R., Sarkar, A., Aldakheel, F. M., Binshaya, A. S., Alharthi, N. S., Alaofi, A. L., Alqahtani, M. S., & Syed, R. (2022). Copper(ii) complexes supported by modified azo-based ligands: Nucleic acid binding and molecular docking studies. Open Chemistry, 20(1), 505-516. https://doi.org/10.1515/chem-2022-0164

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title = "Copper(ii) complexes supported by modified azo-based ligands: Nucleic acid binding and molecular docking studies",

abstract = "Two new copper(ii) complexes [CuL1] (1) and [CuL2] (2) derived from azo-based ligands 2-hydroxy-5-p-tolylazo-benzaldehyde (HL1) and 1-(2-hydroxy-5-p-tolylazo-phenyl)-ethan-one (HL2) were synthesized. These two ligands and their metal complexes were characterized by elemental analysis, nuclear magnetic resonance (1H and 13C), infrared, and UV/Vis spectroscopic techniques. Spectroscopy and other theoretical studies reveal the geometry of copper complexes, and their binding affinity towards nucleic acids are major groove binding.",

keywords = "azo, copper(ii) complexes, ct-DNA, DFT, molecular docking, t-RNA",

author = "Mamta Tripathi and Asatkar, \{Ashish Kumar\} and Stalin Antony and Dash, \{Mrinal Kanti\} and Gourisankar Roymahapatra and Rama Pande and Avijit Sarkar and Aldakheel, \{Fahad M.\} and Binshaya, \{Abdulkarim S.\} and Alharthi, \{Nahed S.\} and Alaofi, \{Ahmed L.\} and Alqahtani, \{Mohammed S.\} and Rabbani Syed",

note = "Publisher Copyright: {\textcopyright} 2022 Mamta Tripathi et al., published by De Gruyter.",

year = "2022",

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doi = "10.1515/chem-2022-0164",

language = "English",

volume = "20",

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T1 - Copper(ii) complexes supported by modified azo-based ligands

T2 - Nucleic acid binding and molecular docking studies

AU - Tripathi, Mamta

AU - Asatkar, Ashish Kumar

AU - Antony, Stalin

AU - Dash, Mrinal Kanti

AU - Roymahapatra, Gourisankar

AU - Pande, Rama

AU - Sarkar, Avijit

AU - Aldakheel, Fahad M.

AU - Binshaya, Abdulkarim S.

AU - Alharthi, Nahed S.

AU - Alaofi, Ahmed L.

AU - Alqahtani, Mohammed S.

AU - Syed, Rabbani

PY - 2022/1/1

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N2 - Two new copper(ii) complexes [CuL1] (1) and [CuL2] (2) derived from azo-based ligands 2-hydroxy-5-p-tolylazo-benzaldehyde (HL1) and 1-(2-hydroxy-5-p-tolylazo-phenyl)-ethan-one (HL2) were synthesized. These two ligands and their metal complexes were characterized by elemental analysis, nuclear magnetic resonance (1H and 13C), infrared, and UV/Vis spectroscopic techniques. Spectroscopy and other theoretical studies reveal the geometry of copper complexes, and their binding affinity towards nucleic acids are major groove binding.

AB - Two new copper(ii) complexes [CuL1] (1) and [CuL2] (2) derived from azo-based ligands 2-hydroxy-5-p-tolylazo-benzaldehyde (HL1) and 1-(2-hydroxy-5-p-tolylazo-phenyl)-ethan-one (HL2) were synthesized. These two ligands and their metal complexes were characterized by elemental analysis, nuclear magnetic resonance (1H and 13C), infrared, and UV/Vis spectroscopic techniques. Spectroscopy and other theoretical studies reveal the geometry of copper complexes, and their binding affinity towards nucleic acids are major groove binding.

KW - azo

KW - copper(ii) complexes

KW - ct-DNA

KW - DFT

KW - molecular docking

KW - t-RNA

UR - https://www.scopus.com/pages/publications/85133432832

U2 - 10.1515/chem-2022-0164

DO - 10.1515/chem-2022-0164

M3 - Article

AN - SCOPUS:85133432832

SN - 2391-5420

VL - 20

SP - 505

EP - 516

JO - Open Chemistry

JF - Open Chemistry

IS - 1

ER -

Copper(ii) complexes supported by modified azo-based ligands: Nucleic acid binding and molecular docking studies

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Keywords

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