TY - JOUR
T1 - Contortisiliosides H–M
T2 - Triterpenoid saponins from Enterolobium contortisiliquum and their biological activity
AU - Abdel-Mageed, Wael M.
AU - Al-Wahaibi, Lamya H.
AU - Gouda, Yaser G.
AU - Al-Saleem, Muneera S.M.
AU - El-Gamal, A. A.
AU - Basudan, Omer A.
AU - Alsaid, Mansour S.
AU - Al-Massarani, Shaza M.
AU - Abdel-Kader, Maged S.
N1 - Publisher Copyright:
© 2019
PY - 2019/11/1
Y1 - 2019/11/1
N2 - Six new triterpenoid saponins, including four bisdesmosidic compounds, contortisiliosides H – K (1 – 4), and two monodesmosidic compounds, contortisiliosides L and M (7, 8), along with two known ones, contortisiliosides E and F (5, 6) were isolated from the ethanolic extract of the pericarps of Enterolobium contortisiliquum (Leguminosae). Their structures were determined using different spectroscopic techniques and acid hydrolysis. The cytotoxic and antimicrobial activities were then evaluated for the isolated compounds. Among isolated saponins, the most potent cytotoxic activity was observed with contortisilioside E (5) toward human hepatocellular carcinoma (IC50 18.9 μM) and human promyelocytic leukemia (IC50 15.6 μM) cell lines. The antimicrobial evaluation performed using serial dilution method to determine the minimum inhibitory concentration (MIC) revealed that contortisilioside L (7) has a moderate antimicrobial activity against Staphylococcus aureus, Escherichia coli, and Candida albicans (MICs = 25 μM).
AB - Six new triterpenoid saponins, including four bisdesmosidic compounds, contortisiliosides H – K (1 – 4), and two monodesmosidic compounds, contortisiliosides L and M (7, 8), along with two known ones, contortisiliosides E and F (5, 6) were isolated from the ethanolic extract of the pericarps of Enterolobium contortisiliquum (Leguminosae). Their structures were determined using different spectroscopic techniques and acid hydrolysis. The cytotoxic and antimicrobial activities were then evaluated for the isolated compounds. Among isolated saponins, the most potent cytotoxic activity was observed with contortisilioside E (5) toward human hepatocellular carcinoma (IC50 18.9 μM) and human promyelocytic leukemia (IC50 15.6 μM) cell lines. The antimicrobial evaluation performed using serial dilution method to determine the minimum inhibitory concentration (MIC) revealed that contortisilioside L (7) has a moderate antimicrobial activity against Staphylococcus aureus, Escherichia coli, and Candida albicans (MICs = 25 μM).
KW - Antimicrobial activity
KW - Cytotoxic activity
KW - Enterolobium contortisiliquum
KW - Leguminosae
KW - Triterpenoid saponins
UR - http://www.scopus.com/inward/record.url?scp=85068390077&partnerID=8YFLogxK
U2 - 10.1016/j.indcrop.2019.111528
DO - 10.1016/j.indcrop.2019.111528
M3 - Article
AN - SCOPUS:85068390077
SN - 0926-6690
VL - 139
JO - Industrial Crops and Products
JF - Industrial Crops and Products
M1 - 111528
ER -
