Construction of 1,3-disubstituted 4-oxo-1,4-dihydroquinolines as a potential antibacterial agents

Farag A. El-Essawy; Nader M. Boshta; Mshari A. Alotaibi; Mohamed S. Elsayed; Reda Tarabees; Ebtsam A. Saleh

doi:10.1007/s11164-016-2586-8

Construction of 1,3-disubstituted 4-oxo-1,4-dihydroquinolines as a potential antibacterial agents

Farag A. El-Essawy, Nader M. Boshta, Mshari A. Alotaibi, Mohamed S. Elsayed, Reda Tarabees, Ebtsam A. Saleh

Research output: Contribution to journal › Article › peer-review

11 Scopus citations

Abstract

A novel series of 1,3-disubstituted 4-oxo-1,4-dihydroquinolines as antimicrobial agents were designed and synthesized. Their structures have been confirmed using spectroscopic analyses (IR, NMR, and EI-MS). Most of the newly prepared compounds were screened for their antimicrobial activities against two Gram-positive bacterial strains and six Gram-negative bacterial strains. Many of the synthesized compounds displayed a high antimicrobial activity in comparison with reference drugs, for example compounds 4–6, 15, 17, and 18.

Original language	English
Pages (from-to)	8157-8174
Number of pages	18
Journal	Research on Chemical Intermediates
Volume	42
Issue number	12
DOIs	https://doi.org/10.1007/s11164-016-2586-8
State	Published - 1 Dec 2016

Keywords

4-Oxo-1,4-dihydroquinolines
Antimicrobial
Quinolone
Synthesis

Access to Document

10.1007/s11164-016-2586-8

Cite this

@article{77d4be6d9a644634a4f6c27edf984935,

title = "Construction of 1,3-disubstituted 4-oxo-1,4-dihydroquinolines as a potential antibacterial agents",

abstract = "A novel series of 1,3-disubstituted 4-oxo-1,4-dihydroquinolines as antimicrobial agents were designed and synthesized. Their structures have been confirmed using spectroscopic analyses (IR, NMR, and EI-MS). Most of the newly prepared compounds were screened for their antimicrobial activities against two Gram-positive bacterial strains and six Gram-negative bacterial strains. Many of the synthesized compounds displayed a high antimicrobial activity in comparison with reference drugs, for example compounds 4–6, 15, 17, and 18.",

keywords = "4-Oxo-1,4-dihydroquinolines, Antimicrobial, Quinolone, Synthesis",

author = "El-Essawy, \{Farag A.\} and Boshta, \{Nader M.\} and Alotaibi, \{Mshari A.\} and Elsayed, \{Mohamed S.\} and Reda Tarabees and Saleh, \{Ebtsam A.\}",

note = "Publisher Copyright: {\textcopyright} 2016, Springer Science+Business Media Dordrecht.",

year = "2016",

month = dec,

day = "1",

doi = "10.1007/s11164-016-2586-8",

language = "English",

volume = "42",

pages = "8157--8174",

journal = "Research on Chemical Intermediates",

issn = "0922-6168",

publisher = "Springer Netherlands",

number = "12",

}

TY - JOUR

T1 - Construction of 1,3-disubstituted 4-oxo-1,4-dihydroquinolines as a potential antibacterial agents

AU - El-Essawy, Farag A.

AU - Boshta, Nader M.

AU - Alotaibi, Mshari A.

AU - Elsayed, Mohamed S.

AU - Tarabees, Reda

AU - Saleh, Ebtsam A.

PY - 2016/12/1

Y1 - 2016/12/1

N2 - A novel series of 1,3-disubstituted 4-oxo-1,4-dihydroquinolines as antimicrobial agents were designed and synthesized. Their structures have been confirmed using spectroscopic analyses (IR, NMR, and EI-MS). Most of the newly prepared compounds were screened for their antimicrobial activities against two Gram-positive bacterial strains and six Gram-negative bacterial strains. Many of the synthesized compounds displayed a high antimicrobial activity in comparison with reference drugs, for example compounds 4–6, 15, 17, and 18.

AB - A novel series of 1,3-disubstituted 4-oxo-1,4-dihydroquinolines as antimicrobial agents were designed and synthesized. Their structures have been confirmed using spectroscopic analyses (IR, NMR, and EI-MS). Most of the newly prepared compounds were screened for their antimicrobial activities against two Gram-positive bacterial strains and six Gram-negative bacterial strains. Many of the synthesized compounds displayed a high antimicrobial activity in comparison with reference drugs, for example compounds 4–6, 15, 17, and 18.

KW - 4-Oxo-1,4-dihydroquinolines

KW - Antimicrobial

KW - Quinolone

KW - Synthesis

UR - http://www.scopus.com/inward/record.url?scp=84977118109&partnerID=8YFLogxK

U2 - 10.1007/s11164-016-2586-8

DO - 10.1007/s11164-016-2586-8

M3 - Article

AN - SCOPUS:84977118109

SN - 0922-6168

VL - 42

SP - 8157

EP - 8174

JO - Research on Chemical Intermediates

JF - Research on Chemical Intermediates

IS - 12

ER -

Construction of 1,3-disubstituted 4-oxo-1,4-dihydroquinolines as a potential antibacterial agents

Abstract

Keywords

Access to Document

Other files and links

Fingerprint

Cite this