Comprehensive review on biosensors based on integration of aptamer and magnetic nanomaterials for food analysis

Background: There is no doubt that food safety has a knock-on effect on our lives from different perspectives. the analysis of foodborne pathogenic bacteria, antibiotics, pesticides, mycotoxins, and biotoxins can broaden our horizons about foodborne diseases and economic barriers. Recently, versatile biosensors based on magnetic nanomaterials (MNMs) and aptamer (Apt) have attracted considerable attention in terms of food analysis due to their several advantages such as sensitivity, fast response time, selectivity, and affordability. Method: The presence of MNMs in the structure of a probe can bring about detection, and purification analysis of food contaminations from complex matrices. The superparamagnetic property of MNMs can qualify them to be used in different analytical methods. To provide specificity probe, several functionalized groups on the surface of MNMs can introduce an excellent substrate for the immobilization of Apt. The chemical stability of this ligand enables controlled chemical modification with other types of nanomaterials can boost the performance of these biosensing approaches. Significant findings: Aptasensors based on MNMs introduce analytical approaches for detection of food contamination, in this review, recent advances in aptasensors based on MNMs were reviewed. Working strategies as well as benefits and limitations of researches are discussed, followed by challenges and prospects.