Comparison of Salivary IGF-1, IGFBP-3, and CTX with Periodontal Status among Patients Belonging to Various Skeletal Maturity Groups

Abdullah Almalk; Julie Toby Thomas; Mohamed Helmy Salama; Sara Ayid Alghamdi; Basim Almulhim; Abdullah Alassaff; Betsy Josephg; Ali Alqerban

doi:10.3290/j.ohpd.b2805419

Comparison of Salivary IGF-1, IGFBP-3, and CTX with Periodontal Status among Patients Belonging to Various Skeletal Maturity Groups

Abdullah Almalk
, Julie Toby Thomas
, Mohamed Helmy Salama
, Sara Ayid Alghamdi
, Basim Almulhim
, Abdullah Alassaff
, Betsy Josephg
, Ali Alqerban

Preventive Dental Sciences

Majmaah University
Saveetha Institute of Medical and Technical Sciences (Deemed to be University)

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Abstract

Purpose: To compare the levels of salivary IGF-1, IGFBP-3, and CTX with periodontal status among patients belonging to various skeletal maturity groups. Materials and Methods: This cross-sectional study was conducted on 80 participants 6 to 25 years of age. Based on skeletal maturity, the participants were categorised into 3 different stages: prepubertal, pubertal, and post-pubertal stages. The periodontal status of the participants was assessed using the simplified oral hygiene index (OHI-S), bleeding on probing (BOP), probing pocket depth (PPD), clinical attachment loss (CAL), and community periodontal index (CPI). The saliva samples were examined for IGF-1, IGFBP-3, and CTX using the respective ELISA kits. One-way ANOVA was used to determine statistically significant differences of means across the study groups for continuous variables. Results The study demonstrated statistically significant differences for the parameters OHI-S, bleeding on probing, PPD, CPI, and CAL (p 0.05) depending on skeletal maturity stage. ANOVA test showed a statistically significant difference by stage in IGF-1, IGFPB3, and CTX (p 0.01). Conclusion An association exists between periodontal status and levels of salivary IGF-1, IGFBP-3, and CTX in pa tients belonging to various skeletal maturity groups.

Original language	English
Pages (from-to)	103-111
Number of pages	9
Journal	Oral Health and Preventive Dentistry
Volume	20
Issue number	1
DOIs	https://doi.org/10.3290/j.ohpd.b2805419
State	Published - 2022

Keywords

C-terminal telopeptide region of type i collagen
Igf-binding protein-3
Insulin-like growth factors
Peri odontitis
Skeletal maturity

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10.3290/j.ohpd.b2805419

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@article{e35ec7df46ed45278875e69a0ae0b0cf,

title = "Comparison of Salivary IGF-1, IGFBP-3, and CTX with Periodontal Status among Patients Belonging to Various Skeletal Maturity Groups",

abstract = "Purpose: To compare the levels of salivary IGF-1, IGFBP-3, and CTX with periodontal status among patients belonging to various skeletal maturity groups. Materials and Methods: This cross-sectional study was conducted on 80 participants 6 to 25 years of age. Based on skeletal maturity, the participants were categorised into 3 different stages: prepubertal, pubertal, and post-pubertal stages. The periodontal status of the participants was assessed using the simplified oral hygiene index (OHI-S), bleeding on probing (BOP), probing pocket depth (PPD), clinical attachment loss (CAL), and community periodontal index (CPI). The saliva samples were examined for IGF-1, IGFBP-3, and CTX using the respective ELISA kits. One-way ANOVA was used to determine statistically significant differences of means across the study groups for continuous variables. Results The study demonstrated statistically significant differences for the parameters OHI-S, bleeding on probing, PPD, CPI, and CAL (p 0.05) depending on skeletal maturity stage. ANOVA test showed a statistically significant difference by stage in IGF-1, IGFPB3, and CTX (p 0.01). Conclusion An association exists between periodontal status and levels of salivary IGF-1, IGFBP-3, and CTX in pa tients belonging to various skeletal maturity groups.",

keywords = "C-terminal telopeptide region of type i collagen, Igf-binding protein-3, Insulin-like growth factors, Peri odontitis, Skeletal maturity",

author = "Abdullah Almalk and Thomas, \{Julie Toby\} and Salama, \{Mohamed Helmy\} and Alghamdi, \{Sara Ayid\} and Basim Almulhim and Abdullah Alassaff and Betsy Josephg and Ali Alqerban",

note = "Publisher Copyright: {\textcopyright} This work is licensed under the Creative Commons Attribution 4.0 International License.",

year = "2022",

doi = "10.3290/j.ohpd.b2805419",

language = "English",

volume = "20",

pages = "103--111",

journal = "Oral Health and Preventive Dentistry",

issn = "1602-1622",

publisher = "Quintessence Publishing Co. Inc.",

number = "1",

}

TY - JOUR

T1 - Comparison of Salivary IGF-1, IGFBP-3, and CTX with Periodontal Status among Patients Belonging to Various Skeletal Maturity Groups

AU - Almalk, Abdullah

AU - Thomas, Julie Toby

AU - Salama, Mohamed Helmy

AU - Alghamdi, Sara Ayid

AU - Almulhim, Basim

AU - Alassaff, Abdullah

AU - Josephg, Betsy

AU - Alqerban, Ali

N1 - Publisher Copyright: © This work is licensed under the Creative Commons Attribution 4.0 International License.

PY - 2022

Y1 - 2022

N2 - Purpose: To compare the levels of salivary IGF-1, IGFBP-3, and CTX with periodontal status among patients belonging to various skeletal maturity groups. Materials and Methods: This cross-sectional study was conducted on 80 participants 6 to 25 years of age. Based on skeletal maturity, the participants were categorised into 3 different stages: prepubertal, pubertal, and post-pubertal stages. The periodontal status of the participants was assessed using the simplified oral hygiene index (OHI-S), bleeding on probing (BOP), probing pocket depth (PPD), clinical attachment loss (CAL), and community periodontal index (CPI). The saliva samples were examined for IGF-1, IGFBP-3, and CTX using the respective ELISA kits. One-way ANOVA was used to determine statistically significant differences of means across the study groups for continuous variables. Results The study demonstrated statistically significant differences for the parameters OHI-S, bleeding on probing, PPD, CPI, and CAL (p 0.05) depending on skeletal maturity stage. ANOVA test showed a statistically significant difference by stage in IGF-1, IGFPB3, and CTX (p 0.01). Conclusion An association exists between periodontal status and levels of salivary IGF-1, IGFBP-3, and CTX in pa tients belonging to various skeletal maturity groups.

AB - Purpose: To compare the levels of salivary IGF-1, IGFBP-3, and CTX with periodontal status among patients belonging to various skeletal maturity groups. Materials and Methods: This cross-sectional study was conducted on 80 participants 6 to 25 years of age. Based on skeletal maturity, the participants were categorised into 3 different stages: prepubertal, pubertal, and post-pubertal stages. The periodontal status of the participants was assessed using the simplified oral hygiene index (OHI-S), bleeding on probing (BOP), probing pocket depth (PPD), clinical attachment loss (CAL), and community periodontal index (CPI). The saliva samples were examined for IGF-1, IGFBP-3, and CTX using the respective ELISA kits. One-way ANOVA was used to determine statistically significant differences of means across the study groups for continuous variables. Results The study demonstrated statistically significant differences for the parameters OHI-S, bleeding on probing, PPD, CPI, and CAL (p 0.05) depending on skeletal maturity stage. ANOVA test showed a statistically significant difference by stage in IGF-1, IGFPB3, and CTX (p 0.01). Conclusion An association exists between periodontal status and levels of salivary IGF-1, IGFBP-3, and CTX in pa tients belonging to various skeletal maturity groups.

KW - C-terminal telopeptide region of type i collagen

KW - Igf-binding protein-3

KW - Insulin-like growth factors

KW - Peri odontitis

KW - Skeletal maturity

UR - https://www.scopus.com/pages/publications/85126417800

U2 - 10.3290/j.ohpd.b2805419

DO - 10.3290/j.ohpd.b2805419

M3 - Article

C2 - 35285598

AN - SCOPUS:85126417800

SN - 1602-1622

VL - 20

SP - 103

EP - 111

JO - Oral Health and Preventive Dentistry

JF - Oral Health and Preventive Dentistry

IS - 1

ER -

Comparison of Salivary IGF-1, IGFBP-3, and CTX with Periodontal Status among Patients Belonging to Various Skeletal Maturity Groups

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