TY - JOUR
T1 - Comparison of Salivary IGF-1, IGFBP-3, and CTX with Periodontal Status among Patients Belonging to Various Skeletal Maturity Groups
AU - Almalk, Abdullah
AU - Thomas, Julie Toby
AU - Salama, Mohamed Helmy
AU - Alghamdi, Sara Ayid
AU - Almulhim, Basim
AU - Alassaff, Abdullah
AU - Josephg, Betsy
AU - Alqerban, Ali
N1 - Publisher Copyright:
© This work is licensed under the Creative Commons Attribution 4.0 International License.
PY - 2022
Y1 - 2022
N2 - Purpose: To compare the levels of salivary IGF-1, IGFBP-3, and CTX with periodontal status among patients belonging to various skeletal maturity groups. Materials and Methods: This cross-sectional study was conducted on 80 participants 6 to 25 years of age. Based on skeletal maturity, the participants were categorised into 3 different stages: prepubertal, pubertal, and post-pubertal stages. The periodontal status of the participants was assessed using the simplified oral hygiene index (OHI-S), bleeding on probing (BOP), probing pocket depth (PPD), clinical attachment loss (CAL), and community periodontal index (CPI). The saliva samples were examined for IGF-1, IGFBP-3, and CTX using the respective ELISA kits. One-way ANOVA was used to determine statistically significant differences of means across the study groups for continuous variables. Results The study demonstrated statistically significant differences for the parameters OHI-S, bleeding on probing, PPD, CPI, and CAL (p 0.05) depending on skeletal maturity stage. ANOVA test showed a statistically significant difference by stage in IGF-1, IGFPB3, and CTX (p 0.01). Conclusion An association exists between periodontal status and levels of salivary IGF-1, IGFBP-3, and CTX in pa tients belonging to various skeletal maturity groups.
AB - Purpose: To compare the levels of salivary IGF-1, IGFBP-3, and CTX with periodontal status among patients belonging to various skeletal maturity groups. Materials and Methods: This cross-sectional study was conducted on 80 participants 6 to 25 years of age. Based on skeletal maturity, the participants were categorised into 3 different stages: prepubertal, pubertal, and post-pubertal stages. The periodontal status of the participants was assessed using the simplified oral hygiene index (OHI-S), bleeding on probing (BOP), probing pocket depth (PPD), clinical attachment loss (CAL), and community periodontal index (CPI). The saliva samples were examined for IGF-1, IGFBP-3, and CTX using the respective ELISA kits. One-way ANOVA was used to determine statistically significant differences of means across the study groups for continuous variables. Results The study demonstrated statistically significant differences for the parameters OHI-S, bleeding on probing, PPD, CPI, and CAL (p 0.05) depending on skeletal maturity stage. ANOVA test showed a statistically significant difference by stage in IGF-1, IGFPB3, and CTX (p 0.01). Conclusion An association exists between periodontal status and levels of salivary IGF-1, IGFBP-3, and CTX in pa tients belonging to various skeletal maturity groups.
KW - C-terminal telopeptide region of type i collagen
KW - Igf-binding protein-3
KW - Insulin-like growth factors
KW - Peri odontitis
KW - Skeletal maturity
UR - https://www.scopus.com/pages/publications/85126417800
U2 - 10.3290/j.ohpd.b2805419
DO - 10.3290/j.ohpd.b2805419
M3 - Article
C2 - 35285598
AN - SCOPUS:85126417800
SN - 1602-1622
VL - 20
SP - 103
EP - 111
JO - Oral Health and Preventive Dentistry
JF - Oral Health and Preventive Dentistry
IS - 1
ER -