Comparative efficacy of alpha-linolenic acid and gamma-linolenic acid to attenuate valproic acid-induced autism-like features

Sneha Yadav; Virendra Tiwari; Manjari Singh; Rajnish K. Yadav; Subhadeep Roy; Uma Devi; Swetlana Gautam; Jitendra Kumar Rawat; Mohd Nazam Ansari; Abdulaziz Sa Saeedan; Anand Prakash; Shubhini A. Saraf; Gaurav Kaithwas

doi:10.1007/s13105-016-0532-2

Comparative efficacy of alpha-linolenic acid and gamma-linolenic acid to attenuate valproic acid-induced autism-like features

Sneha Yadav
, Virendra Tiwari
, Manjari Singh
, Rajnish K. Yadav
, Subhadeep Roy
, Uma Devi
, Swetlana Gautam
, Jitendra Kumar Rawat
, Mohd Nazam Ansari
, Abdulaziz Sa Saeedan
, Anand Prakash
, Shubhini A. Saraf
, Gaurav Kaithwas

Pharmacology

Research output: Contribution to journal › Article › peer-review

26 Scopus citations

Abstract

The present study was undertaken to elucidate the effect of alpha-linolenic acid (ALA, 18:3, ω-3) and gamma-linolenic acid (GLA, 18:3, ω-6) on experimental autism features induced by early prenatal exposure to valproic acid (VPA) in albino wistar pups. The pups were scrutinized on the accounts of behavioral, biochemical, and inflammatory markers, and the results suggested that the GLA can impart significant protection in comparison to ALA against VPA-induced autism features. When scrutinized histopathologically, the cerebellum of the GLA-treated animals was evident for more marked protection toward neuronal degeneration and neuronal loss in comparison to ALA. Concomitant administration of ALA and GLA with VPA demonstrated a marked cutdown in the Pgp 9.5 expression with GLA having more pronounced effect. Henceforth, it can be concluded that ALA and GLA can impart favorable protection against the VPA-induced autism-like features with GLA having pronounced effect.

Original language	English
Pages (from-to)	187-198
Number of pages	12
Journal	Journal of Physiology and Biochemistry
Volume	73
Issue number	2
DOIs	https://doi.org/10.1007/s13105-016-0532-2
State	Published - 1 May 2017

Keywords

Alpha-linolenic acid
Autism spectrum disorder
Gamma-linolenic acid
Pgp 9.5
Polyunsaturated fatty acids

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10.1007/s13105-016-0532-2

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Yadav, S., Tiwari, V., Singh, M., Yadav, R. K., Roy, S., Devi, U., Gautam, S., Rawat, J. K., Ansari, M. N., Saeedan, A. S., Prakash, A., Saraf, S. A., & Kaithwas, G. (2017). Comparative efficacy of alpha-linolenic acid and gamma-linolenic acid to attenuate valproic acid-induced autism-like features. Journal of Physiology and Biochemistry, 73(2), 187-198. https://doi.org/10.1007/s13105-016-0532-2

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title = "Comparative efficacy of alpha-linolenic acid and gamma-linolenic acid to attenuate valproic acid-induced autism-like features",

abstract = "The present study was undertaken to elucidate the effect of alpha-linolenic acid (ALA, 18:3, ω-3) and gamma-linolenic acid (GLA, 18:3, ω-6) on experimental autism features induced by early prenatal exposure to valproic acid (VPA) in albino wistar pups. The pups were scrutinized on the accounts of behavioral, biochemical, and inflammatory markers, and the results suggested that the GLA can impart significant protection in comparison to ALA against VPA-induced autism features. When scrutinized histopathologically, the cerebellum of the GLA-treated animals was evident for more marked protection toward neuronal degeneration and neuronal loss in comparison to ALA. Concomitant administration of ALA and GLA with VPA demonstrated a marked cutdown in the Pgp 9.5 expression with GLA having more pronounced effect. Henceforth, it can be concluded that ALA and GLA can impart favorable protection against the VPA-induced autism-like features with GLA having pronounced effect.",

keywords = "Alpha-linolenic acid, Autism spectrum disorder, Gamma-linolenic acid, Pgp 9.5, Polyunsaturated fatty acids",

author = "Sneha Yadav and Virendra Tiwari and Manjari Singh and Yadav, \{Rajnish K.\} and Subhadeep Roy and Uma Devi and Swetlana Gautam and Rawat, \{Jitendra Kumar\} and Ansari, \{Mohd Nazam\} and Saeedan, \{Abdulaziz Sa\} and Anand Prakash and Saraf, \{Shubhini A.\} and Gaurav Kaithwas",

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doi = "10.1007/s13105-016-0532-2",

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Yadav, S, Tiwari, V, Singh, M, Yadav, RK, Roy, S, Devi, U, Gautam, S, Rawat, JK, Ansari, MN , Saeedan, AS, Prakash, A, Saraf, SA & Kaithwas, G 2017, 'Comparative efficacy of alpha-linolenic acid and gamma-linolenic acid to attenuate valproic acid-induced autism-like features', Journal of Physiology and Biochemistry, vol. 73, no. 2, pp. 187-198. https://doi.org/10.1007/s13105-016-0532-2

TY - JOUR

T1 - Comparative efficacy of alpha-linolenic acid and gamma-linolenic acid to attenuate valproic acid-induced autism-like features

AU - Yadav, Sneha

AU - Tiwari, Virendra

AU - Singh, Manjari

AU - Yadav, Rajnish K.

AU - Roy, Subhadeep

AU - Devi, Uma

AU - Gautam, Swetlana

AU - Rawat, Jitendra Kumar

AU - Ansari, Mohd Nazam

AU - Saeedan, Abdulaziz Sa

AU - Prakash, Anand

AU - Saraf, Shubhini A.

AU - Kaithwas, Gaurav

PY - 2017/5/1

Y1 - 2017/5/1

N2 - The present study was undertaken to elucidate the effect of alpha-linolenic acid (ALA, 18:3, ω-3) and gamma-linolenic acid (GLA, 18:3, ω-6) on experimental autism features induced by early prenatal exposure to valproic acid (VPA) in albino wistar pups. The pups were scrutinized on the accounts of behavioral, biochemical, and inflammatory markers, and the results suggested that the GLA can impart significant protection in comparison to ALA against VPA-induced autism features. When scrutinized histopathologically, the cerebellum of the GLA-treated animals was evident for more marked protection toward neuronal degeneration and neuronal loss in comparison to ALA. Concomitant administration of ALA and GLA with VPA demonstrated a marked cutdown in the Pgp 9.5 expression with GLA having more pronounced effect. Henceforth, it can be concluded that ALA and GLA can impart favorable protection against the VPA-induced autism-like features with GLA having pronounced effect.

AB - The present study was undertaken to elucidate the effect of alpha-linolenic acid (ALA, 18:3, ω-3) and gamma-linolenic acid (GLA, 18:3, ω-6) on experimental autism features induced by early prenatal exposure to valproic acid (VPA) in albino wistar pups. The pups were scrutinized on the accounts of behavioral, biochemical, and inflammatory markers, and the results suggested that the GLA can impart significant protection in comparison to ALA against VPA-induced autism features. When scrutinized histopathologically, the cerebellum of the GLA-treated animals was evident for more marked protection toward neuronal degeneration and neuronal loss in comparison to ALA. Concomitant administration of ALA and GLA with VPA demonstrated a marked cutdown in the Pgp 9.5 expression with GLA having more pronounced effect. Henceforth, it can be concluded that ALA and GLA can impart favorable protection against the VPA-induced autism-like features with GLA having pronounced effect.

KW - Alpha-linolenic acid

KW - Autism spectrum disorder

KW - Gamma-linolenic acid

KW - Pgp 9.5

KW - Polyunsaturated fatty acids

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DO - 10.1007/s13105-016-0532-2

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C2 - 27878518

AN - SCOPUS:84996598115

SN - 1138-7548

VL - 73

SP - 187

EP - 198

JO - Journal of Physiology and Biochemistry

JF - Journal of Physiology and Biochemistry

IS - 2

ER -

Comparative efficacy of alpha-linolenic acid and gamma-linolenic acid to attenuate valproic acid-induced autism-like features

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Keywords

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