TY - JOUR
T1 - Comparative efficacy of alpha-linolenic acid and gamma-linolenic acid to attenuate valproic acid-induced autism-like features
AU - Yadav, Sneha
AU - Tiwari, Virendra
AU - Singh, Manjari
AU - Yadav, Rajnish K.
AU - Roy, Subhadeep
AU - Devi, Uma
AU - Gautam, Swetlana
AU - Rawat, Jitendra Kumar
AU - Ansari, Mohd Nazam
AU - Saeedan, Abdulaziz Sa
AU - Prakash, Anand
AU - Saraf, Shubhini A.
AU - Kaithwas, Gaurav
N1 - Publisher Copyright:
© 2016, University of Navarra.
PY - 2017/5/1
Y1 - 2017/5/1
N2 - The present study was undertaken to elucidate the effect of alpha-linolenic acid (ALA, 18:3, ω-3) and gamma-linolenic acid (GLA, 18:3, ω-6) on experimental autism features induced by early prenatal exposure to valproic acid (VPA) in albino wistar pups. The pups were scrutinized on the accounts of behavioral, biochemical, and inflammatory markers, and the results suggested that the GLA can impart significant protection in comparison to ALA against VPA-induced autism features. When scrutinized histopathologically, the cerebellum of the GLA-treated animals was evident for more marked protection toward neuronal degeneration and neuronal loss in comparison to ALA. Concomitant administration of ALA and GLA with VPA demonstrated a marked cutdown in the Pgp 9.5 expression with GLA having more pronounced effect. Henceforth, it can be concluded that ALA and GLA can impart favorable protection against the VPA-induced autism-like features with GLA having pronounced effect.
AB - The present study was undertaken to elucidate the effect of alpha-linolenic acid (ALA, 18:3, ω-3) and gamma-linolenic acid (GLA, 18:3, ω-6) on experimental autism features induced by early prenatal exposure to valproic acid (VPA) in albino wistar pups. The pups were scrutinized on the accounts of behavioral, biochemical, and inflammatory markers, and the results suggested that the GLA can impart significant protection in comparison to ALA against VPA-induced autism features. When scrutinized histopathologically, the cerebellum of the GLA-treated animals was evident for more marked protection toward neuronal degeneration and neuronal loss in comparison to ALA. Concomitant administration of ALA and GLA with VPA demonstrated a marked cutdown in the Pgp 9.5 expression with GLA having more pronounced effect. Henceforth, it can be concluded that ALA and GLA can impart favorable protection against the VPA-induced autism-like features with GLA having pronounced effect.
KW - Alpha-linolenic acid
KW - Autism spectrum disorder
KW - Gamma-linolenic acid
KW - Pgp 9.5
KW - Polyunsaturated fatty acids
UR - https://www.scopus.com/pages/publications/84996598115
U2 - 10.1007/s13105-016-0532-2
DO - 10.1007/s13105-016-0532-2
M3 - Article
C2 - 27878518
AN - SCOPUS:84996598115
SN - 1138-7548
VL - 73
SP - 187
EP - 198
JO - Journal of Physiology and Biochemistry
JF - Journal of Physiology and Biochemistry
IS - 2
ER -