Coagulation Dysfunctions: A Hallmarks for Thrombo-Inflammatory Risks in SARS-CoV-2 Hospitalized Patients

Lienda Bashier Eltayeb; Abda Hassan Ali; Elharam Ibrahim Abdallah; Alaa Eltayeb Omer; Mudathir A.A. Abakar; Wala Eldin Elradi; Altaf Ali Mangi; Bdul Aziz Babar

Coagulation Dysfunctions: A Hallmarks for Thrombo-Inflammatory Risks in SARS-CoV-2 Hospitalized Patients

Lienda Bashier Eltayeb, Abda Hassan Ali, Elharam Ibrahim Abdallah, Alaa Eltayeb Omer, Mudathir A.A. Abakar, Wala Eldin Elradi, Altaf Ali Mangi, Bdul Aziz Babar

Medical Laboratory Sciences

Research output: Contribution to journal › Article › peer-review

Abstract

The relevance of coagulation malfunction in COVID-19 (severe coronavirus disease) is ambiguous. Current study aimed to assess the coagulation among SARS-CoV-2 hospitalized patients. A cross sectional study with qualitative approach was conducted among 300 patients who are already diagnosed as COVID 19 compared to 300 apparently healthy control group attended to Red Sea State during study period from April 2020 to April 2021. The Humaclot Due Plus1 coagulation analyser was used to estimate the prothrombin time (PT), activated partial prothrombin time (APTT), and international normalized ratio (INR) (Wiesbaden 1, Germany), adding 25 μL of plasma in cuvette. The study result showed that in COVID-19 patients D.dimer level is high (2000-10000 ng/mL) compared with control group (up to 500 ng/mL). COVID-19 infection cause high D. dimer level which can lead to thrombosis event or bleeding tendency. Abnormal coagulation results were revealed among SARS-CoV-2, with markedly elevated D. dimer.

Original language	English
Pages (from-to)	357-363
Number of pages	7
Journal	Latin American Journal of Pharmacy
Volume	41
Issue number	2
State	Published - 2022

Keywords

coagulation parameter
D-dimer
disseminated intravascular coagulation
SARS-CoV-2

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Cite this

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title = "Coagulation Dysfunctions: A Hallmarks for Thrombo-Inflammatory Risks in SARS-CoV-2 Hospitalized Patients",

abstract = "The relevance of coagulation malfunction in COVID-19 (severe coronavirus disease) is ambiguous. Current study aimed to assess the coagulation among SARS-CoV-2 hospitalized patients. A cross sectional study with qualitative approach was conducted among 300 patients who are already diagnosed as COVID 19 compared to 300 apparently healthy control group attended to Red Sea State during study period from April 2020 to April 2021. The Humaclot Due Plus1 coagulation analyser was used to estimate the prothrombin time (PT), activated partial prothrombin time (APTT), and international normalized ratio (INR) (Wiesbaden 1, Germany), adding 25 μL of plasma in cuvette. The study result showed that in COVID-19 patients D.dimer level is high (2000-10000 ng/mL) compared with control group (up to 500 ng/mL). COVID-19 infection cause high D. dimer level which can lead to thrombosis event or bleeding tendency. Abnormal coagulation results were revealed among SARS-CoV-2, with markedly elevated D. dimer.",

keywords = "coagulation parameter, D-dimer, disseminated intravascular coagulation, SARS-CoV-2",

author = "Eltayeb, \{Lienda Bashier\} and Ali, \{Abda Hassan\} and Abdallah, \{Elharam Ibrahim\} and Omer, \{Alaa Eltayeb\} and Abakar, \{Mudathir A.A.\} and Elradi, \{Wala Eldin\} and Mangi, \{Altaf Ali\} and Babar, \{Bdul Aziz\}",

year = "2022",

language = "English",

volume = "41",

pages = "357--363",

journal = "Latin American Journal of Pharmacy",

issn = "0326-2383",

publisher = "Colegio de Farmaceuticos de la Provincia de Buenos Aires",

number = "2",

}

TY - JOUR

T1 - Coagulation Dysfunctions

T2 - A Hallmarks for Thrombo-Inflammatory Risks in SARS-CoV-2 Hospitalized Patients

AU - Eltayeb, Lienda Bashier

AU - Ali, Abda Hassan

AU - Abdallah, Elharam Ibrahim

AU - Omer, Alaa Eltayeb

AU - Abakar, Mudathir A.A.

AU - Elradi, Wala Eldin

AU - Mangi, Altaf Ali

AU - Babar, Bdul Aziz

PY - 2022

Y1 - 2022

N2 - The relevance of coagulation malfunction in COVID-19 (severe coronavirus disease) is ambiguous. Current study aimed to assess the coagulation among SARS-CoV-2 hospitalized patients. A cross sectional study with qualitative approach was conducted among 300 patients who are already diagnosed as COVID 19 compared to 300 apparently healthy control group attended to Red Sea State during study period from April 2020 to April 2021. The Humaclot Due Plus1 coagulation analyser was used to estimate the prothrombin time (PT), activated partial prothrombin time (APTT), and international normalized ratio (INR) (Wiesbaden 1, Germany), adding 25 μL of plasma in cuvette. The study result showed that in COVID-19 patients D.dimer level is high (2000-10000 ng/mL) compared with control group (up to 500 ng/mL). COVID-19 infection cause high D. dimer level which can lead to thrombosis event or bleeding tendency. Abnormal coagulation results were revealed among SARS-CoV-2, with markedly elevated D. dimer.

AB - The relevance of coagulation malfunction in COVID-19 (severe coronavirus disease) is ambiguous. Current study aimed to assess the coagulation among SARS-CoV-2 hospitalized patients. A cross sectional study with qualitative approach was conducted among 300 patients who are already diagnosed as COVID 19 compared to 300 apparently healthy control group attended to Red Sea State during study period from April 2020 to April 2021. The Humaclot Due Plus1 coagulation analyser was used to estimate the prothrombin time (PT), activated partial prothrombin time (APTT), and international normalized ratio (INR) (Wiesbaden 1, Germany), adding 25 μL of plasma in cuvette. The study result showed that in COVID-19 patients D.dimer level is high (2000-10000 ng/mL) compared with control group (up to 500 ng/mL). COVID-19 infection cause high D. dimer level which can lead to thrombosis event or bleeding tendency. Abnormal coagulation results were revealed among SARS-CoV-2, with markedly elevated D. dimer.

KW - coagulation parameter

KW - D-dimer

KW - disseminated intravascular coagulation

KW - SARS-CoV-2

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M3 - Article

AN - SCOPUS:85135228870

SN - 0326-2383

VL - 41

SP - 357

EP - 363

JO - Latin American Journal of Pharmacy

JF - Latin American Journal of Pharmacy

IS - 2

ER -

Coagulation Dysfunctions: A Hallmarks for Thrombo-Inflammatory Risks in SARS-CoV-2 Hospitalized Patients

Abstract

Keywords

UN SDGs

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