TY - JOUR
T1 - Chemical constituents from Centaurothamnus maximus and their antimicrobial activity
AU - Al-Saleem, Muneera S.M.
AU - Al-Wahaibi, Lamya H.
AU - El-Gamal, Ali A.
AU - Al-Massarani, Shaza M.
AU - Siddiqui, Nasir A.
AU - Basudan, Omer A.
AU - Salem-Bekhit, Mounir M.
AU - Abdel-Kader, Maged S.
AU - El-Gamal, Reem A.
AU - Abdel-Mageed, Wael M.
N1 - Publisher Copyright:
© 2022 Informa UK Limited, trading as Taylor & Francis Group.
PY - 2023
Y1 - 2023
N2 - A new sesquiterpene lactone, 3β,10α-dihydroxy-10β-(hydroxymethyl)-8α-(4-hydroxymethacrylate)-1αH,5αH,6βH,7αH-guai-4(15), 11(13)-dien-6,12-olide (1), along with twenty-one known compounds, were identified from the aerial parts of Centaurothamnus maximus. The structures of the isolated compounds were elucidated on the basis of spectroscopic evidences and correlated with known compounds. Compounds (2, 3, 5‒13 and 15‒22) were identified from C. maximus for the first time. Antibacterial and antifungal activities of the isolated compounds were tested using the agar disc diffusion method. Compounds that demonstrated promising antimicrobial activity were evaluated for their minimum inhibitory concentration (MIC). The results showed that compounds 3 and 7 were the most effective antibacterial compounds against B. subtilis ATCC 6633, S. aureus ATCC 25923 and S. pyogenes ATCC 27736, with MIC estimates between 8 and 32 mg/mL. In addition, compound 2 exhibited the strongest antifungal activity against C. albicans ATCC 14243 and C. krusei ATCC 14243 with MIC 8 mg/mL.
AB - A new sesquiterpene lactone, 3β,10α-dihydroxy-10β-(hydroxymethyl)-8α-(4-hydroxymethacrylate)-1αH,5αH,6βH,7αH-guai-4(15), 11(13)-dien-6,12-olide (1), along with twenty-one known compounds, were identified from the aerial parts of Centaurothamnus maximus. The structures of the isolated compounds were elucidated on the basis of spectroscopic evidences and correlated with known compounds. Compounds (2, 3, 5‒13 and 15‒22) were identified from C. maximus for the first time. Antibacterial and antifungal activities of the isolated compounds were tested using the agar disc diffusion method. Compounds that demonstrated promising antimicrobial activity were evaluated for their minimum inhibitory concentration (MIC). The results showed that compounds 3 and 7 were the most effective antibacterial compounds against B. subtilis ATCC 6633, S. aureus ATCC 25923 and S. pyogenes ATCC 27736, with MIC estimates between 8 and 32 mg/mL. In addition, compound 2 exhibited the strongest antifungal activity against C. albicans ATCC 14243 and C. krusei ATCC 14243 with MIC 8 mg/mL.
KW - antibacterial
KW - antifungal
KW - Asteraceae
KW - Centaurothamnus maximus
KW - sesquiterpene lactone
UR - http://www.scopus.com/inward/record.url?scp=85130418181&partnerID=8YFLogxK
U2 - 10.1080/14786419.2022.2079123
DO - 10.1080/14786419.2022.2079123
M3 - Article
C2 - 35608190
AN - SCOPUS:85130418181
SN - 1478-6419
VL - 37
SP - 693
EP - 701
JO - Natural Product Research
JF - Natural Product Research
IS - 5
ER -