Chemical Composition of Buddleja polystachya Aerial Parts and its Bioactivity against Aedes aegypti

Ali El-Gamal; Shaza Al-Massarani; Ghada Fawzy; Hanan Ati; Adnan Al-Rehaily; Omer Basudan; Maged Abdel-Kader; Nurhayat Tabanca; James Becnel

doi:10.1080/14786419.2017.1378213

Chemical Composition of Buddleja polystachya Aerial Parts and its Bioactivity against Aedes aegypti

Ali El-Gamal, Shaza Al-Massarani, Ghada Fawzy, Hanan Ati, Adnan Al-Rehaily, Omer Basudan, Maged Abdel-Kader, Nurhayat Tabanca, James Becnel

Fharmacognosy

Research output: Contribution to journal › Article › peer-review

10 Scopus citations

Abstract

A new acylatediridoid glycoside, 6-O-α-L-(2″-acetyl-4″-O-trans-isoferuloyl) rhamnopyranosyl catalpol (9) together with 18 known compounds belonging to the iridoids, flavonoids, triterpene saponin glycosides and phenylethanoids (1–8, 10–18) were isolated from the aerial parts and the flowers of Buddleja polystachya. Their structures were elucidated on the basis of spectroscopic evidence and comparison with that reported in the literature. Promising adulticidal activity was shown for all extracts when tested for adulticidal and larvicidal activities against Ae. aegypti mosquitoes. Therefore, isolated compounds (1–10, 12–14 and 19) were bioassayed for their adulticidal activity. Compound 1 (phytol) was highly active with an LD ₅₀ value of 1.27 ± 0.08 μg/mosquito against adult female Ae. aegypti.

Original language	English
Pages (from-to)	2775-2782
Number of pages	8
Journal	Natural Product Research
Volume	32
Issue number	23
DOIs	https://doi.org/10.1080/14786419.2017.1378213
State	Published - 2 Dec 2018

Keywords

acylated iridoid glycosides
adulticidal
Buddleja polystachya
larvicidal

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10.1080/14786419.2017.1378213

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title = "Chemical Composition of Buddleja polystachya Aerial Parts and its Bioactivity against Aedes aegypti",

abstract = " A new acylatediridoid glycoside, 6-O-α-L-(2″-acetyl-4″-O-trans-isoferuloyl) rhamnopyranosyl catalpol (9) together with 18 known compounds belonging to the iridoids, flavonoids, triterpene saponin glycosides and phenylethanoids (1–8, 10–18) were isolated from the aerial parts and the flowers of Buddleja polystachya. Their structures were elucidated on the basis of spectroscopic evidence and comparison with that reported in the literature. Promising adulticidal activity was shown for all extracts when tested for adulticidal and larvicidal activities against Ae. aegypti mosquitoes. Therefore, isolated compounds (1–10, 12–14 and 19) were bioassayed for their adulticidal activity. Compound 1 (phytol) was highly active with an LD 50 value of 1.27 ± 0.08 μg/mosquito against adult female Ae. aegypti.",

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AU - Ati, Hanan

AU - Al-Rehaily, Adnan

AU - Basudan, Omer

AU - Abdel-Kader, Maged

AU - Tabanca, Nurhayat

AU - Becnel, James

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N2 - A new acylatediridoid glycoside, 6-O-α-L-(2″-acetyl-4″-O-trans-isoferuloyl) rhamnopyranosyl catalpol (9) together with 18 known compounds belonging to the iridoids, flavonoids, triterpene saponin glycosides and phenylethanoids (1–8, 10–18) were isolated from the aerial parts and the flowers of Buddleja polystachya. Their structures were elucidated on the basis of spectroscopic evidence and comparison with that reported in the literature. Promising adulticidal activity was shown for all extracts when tested for adulticidal and larvicidal activities against Ae. aegypti mosquitoes. Therefore, isolated compounds (1–10, 12–14 and 19) were bioassayed for their adulticidal activity. Compound 1 (phytol) was highly active with an LD 50 value of 1.27 ± 0.08 μg/mosquito against adult female Ae. aegypti.

AB - A new acylatediridoid glycoside, 6-O-α-L-(2″-acetyl-4″-O-trans-isoferuloyl) rhamnopyranosyl catalpol (9) together with 18 known compounds belonging to the iridoids, flavonoids, triterpene saponin glycosides and phenylethanoids (1–8, 10–18) were isolated from the aerial parts and the flowers of Buddleja polystachya. Their structures were elucidated on the basis of spectroscopic evidence and comparison with that reported in the literature. Promising adulticidal activity was shown for all extracts when tested for adulticidal and larvicidal activities against Ae. aegypti mosquitoes. Therefore, isolated compounds (1–10, 12–14 and 19) were bioassayed for their adulticidal activity. Compound 1 (phytol) was highly active with an LD 50 value of 1.27 ± 0.08 μg/mosquito against adult female Ae. aegypti.

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Chemical Composition of Buddleja polystachya Aerial Parts and its Bioactivity against Aedes aegypti

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