Cell Signaling Pathways in Cancer

Hajir A. Al-Saihati; Mashael Al-Toub; Hanaa I. Sharaf; Manjari Singh; Mohd Nazam Ansari; Abdulaziz Bin Saeedan

doi:10.2174/9789815080384123010009

Cell Signaling Pathways in Cancer

Hajir A. Al-Saihati, Mashael Al-Toub, Hanaa I. Sharaf, Manjari Singh, Mohd Nazam Ansari, Abdulaziz Bin Saeedan

Pharmacology

Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review

1 Scopus citations

Abstract

Cancer is characterized by atypical cell proliferation that has the possibility of dissemination to different body parts. Tumor formation is influenced by genetic mutations and environmental pollutants. The formation and progression of malignancies have been linked to a diversity of molecular paths. The JAK/STAT, NOTCH, PI3K/AKT pathway, mitogen-activated protein kinase (MAPK), transforming growth factor-beta (TGF-beta) (TGF-), NF-B, and Wnt signaling pathways will be highlighted in this chapter. Cancer development has been linked to various changes to the signaling pathways’ components. As a result, various initiatives to target signaling pathways in order to build distinct treatment lines have been approved. In this chapter, we discuss the role of signal transduction in cancer-associated processes and how their targets influence the behavior of the tumor cells.

Original language	English
Title of host publication	Molecular Targets and Cancer Therapeutics
Subtitle of host publication	Part 1
Publisher	Bentham Science Publishers
Pages	242-272
Number of pages	31
ISBN (Electronic)	9789815080384
ISBN (Print)	9789815080391
DOIs	https://doi.org/10.2174/9789815080384123010009
State	Published - 1 Jan 2023

Keywords

Cancer
JAK/STAT
Map Kinase/Erk
NFKB
Notch
PI3K/AKT/mTOR
TGF-β
Wnt/β catenin

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.2174/9789815080384123010009

Cite this

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title = "Cell Signaling Pathways in Cancer",

abstract = "Cancer is characterized by atypical cell proliferation that has the possibility of dissemination to different body parts. Tumor formation is influenced by genetic mutations and environmental pollutants. The formation and progression of malignancies have been linked to a diversity of molecular paths. The JAK/STAT, NOTCH, PI3K/AKT pathway, mitogen-activated protein kinase (MAPK), transforming growth factor-beta (TGF-beta) (TGF-), NF-B, and Wnt signaling pathways will be highlighted in this chapter. Cancer development has been linked to various changes to the signaling pathways{\textquoteright} components. As a result, various initiatives to target signaling pathways in order to build distinct treatment lines have been approved. In this chapter, we discuss the role of signal transduction in cancer-associated processes and how their targets influence the behavior of the tumor cells.",

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T1 - Cell Signaling Pathways in Cancer

AU - Al-Saihati, Hajir A.

AU - Al-Toub, Mashael

AU - Sharaf, Hanaa I.

AU - Singh, Manjari

AU - Ansari, Mohd Nazam

AU - Saeedan, Abdulaziz Bin

PY - 2023/1/1

Y1 - 2023/1/1

N2 - Cancer is characterized by atypical cell proliferation that has the possibility of dissemination to different body parts. Tumor formation is influenced by genetic mutations and environmental pollutants. The formation and progression of malignancies have been linked to a diversity of molecular paths. The JAK/STAT, NOTCH, PI3K/AKT pathway, mitogen-activated protein kinase (MAPK), transforming growth factor-beta (TGF-beta) (TGF-), NF-B, and Wnt signaling pathways will be highlighted in this chapter. Cancer development has been linked to various changes to the signaling pathways’ components. As a result, various initiatives to target signaling pathways in order to build distinct treatment lines have been approved. In this chapter, we discuss the role of signal transduction in cancer-associated processes and how their targets influence the behavior of the tumor cells.

AB - Cancer is characterized by atypical cell proliferation that has the possibility of dissemination to different body parts. Tumor formation is influenced by genetic mutations and environmental pollutants. The formation and progression of malignancies have been linked to a diversity of molecular paths. The JAK/STAT, NOTCH, PI3K/AKT pathway, mitogen-activated protein kinase (MAPK), transforming growth factor-beta (TGF-beta) (TGF-), NF-B, and Wnt signaling pathways will be highlighted in this chapter. Cancer development has been linked to various changes to the signaling pathways’ components. As a result, various initiatives to target signaling pathways in order to build distinct treatment lines have been approved. In this chapter, we discuss the role of signal transduction in cancer-associated processes and how their targets influence the behavior of the tumor cells.

KW - Cancer

KW - JAK/STAT

KW - Map Kinase/Erk

KW - NFKB

KW - Notch

KW - PI3K/AKT/mTOR

KW - TGF-β

KW - Wnt/β catenin

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DO - 10.2174/9789815080384123010009

M3 - Chapter

AN - SCOPUS:85202630875

SN - 9789815080391

SP - 242

EP - 272

BT - Molecular Targets and Cancer Therapeutics

PB - Bentham Science Publishers

ER -

Cell Signaling Pathways in Cancer

Abstract

Keywords

UN SDGs

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