Carbon quantum dots based nanozyme as bio-sensor for enhanced detection of glutathione (U) from cancer cells

Payal Bansal, Mohammad Javed Ansari, Maruthi Rohit Ayyagari, Ramji Kalidoss, Abhishek Madduri, Rahul Kanaoujiya

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

2 Scopus citations

Abstract

Detection of glutathione (GSH), a biomarker in blood for cancer facilitates early detection of cancer. This work focuses on synthesizing carbon dots using Carica papaya fruit as a carbon source and surface passivation with urea. The quenching of carbon dots (U-CDs) which is synthesized by fluorescence is carried out by copper ions whereas recovery of fluorescence was observed by glutathione (GSH) which is a measure of sensitivity. There was an exhibition of functional groups such as carboxyl and hydroxyl on the carbon dot's surface exhibited a high binding affinity for detecting copper ions, while glutathione recovery fluorescence intensity of carbon dots with a LOD of 0.046μM. The fluorescence sensor successfully detected glutathione in commercial drug products. The successful detection of glutathione concentration in cancer cells was carried out by using fluorescence sensor.

Original languageEnglish
Title of host publicationInternational Conference on Biomedical Engineering and Computing Technologies, ICBECT 2022
PublisherAmerican Institute of Physics Inc.
ISBN (Electronic)9780735444430
DOIs
StatePublished - 25 Apr 2023
Event2022 International Conference on Biomedical Engineering and Computing Technologies, ICBECT 2022 - Chennai, India
Duration: 21 Mar 202225 Mar 2022

Publication series

NameAIP Conference Proceedings
Volume2603
ISSN (Print)0094-243X
ISSN (Electronic)1551-7616

Conference

Conference2022 International Conference on Biomedical Engineering and Computing Technologies, ICBECT 2022
Country/TerritoryIndia
CityChennai
Period21/03/2225/03/22

Keywords

  • Biosensor
  • Cancer diagnosis
  • Carica Papaya
  • Glutathione

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