TY - JOUR
T1 - Biotechnological Innovations from Ocean
T2 - Transpiring Role of Marine Drugs in Management of Chronic Disorders
AU - Bhatia, Saurabh
AU - Makkar, Rashita
AU - Behl, Tapan
AU - Sehgal, Aayush
AU - Singh, Sukhbir
AU - Rachamalla, Mahesh
AU - Mani, Vasudevan
AU - Iqbal, Muhammad Shahid
AU - Bungau, Simona Gabriela
N1 - Publisher Copyright:
© 2022 by the authors. Licensee MDPI, Basel, Switzerland.
PY - 2022/3/1
Y1 - 2022/3/1
N2 - Marine drugs are abundant in number, comprise of a diverse range of structures with corresponding mechanisms of action, and hold promise for the discovery of new and better treatment approaches for the management of several chronic diseases. There are huge reserves of natural marine biological compounds, as 70 percent of the Earth is covered with oceans, indicating a diversity of chemical entities on the planet. The marine ecosystems are a rich source of bioactive products and have been explored for lead drug molecules that have proven to be novel therapeutic targets. Over the last 70 years, many structurally diverse drug products and their secondary metabolites have been isolated from marine sources. The drugs obtained from marine sources have displayed an exceptional potential in the management of a wide array of diseases, ranging from acute to chronic conditions. A beneficial role of marine drugs in human health has been recently proposed. The current review highlights various marine drugs and their compounds and role in the management of chronic diseases such as cancer, diabetes, neurodegenerative diseases, and cardiovascular disorders, which has led to the development of new drug treatment approaches.
AB - Marine drugs are abundant in number, comprise of a diverse range of structures with corresponding mechanisms of action, and hold promise for the discovery of new and better treatment approaches for the management of several chronic diseases. There are huge reserves of natural marine biological compounds, as 70 percent of the Earth is covered with oceans, indicating a diversity of chemical entities on the planet. The marine ecosystems are a rich source of bioactive products and have been explored for lead drug molecules that have proven to be novel therapeutic targets. Over the last 70 years, many structurally diverse drug products and their secondary metabolites have been isolated from marine sources. The drugs obtained from marine sources have displayed an exceptional potential in the management of a wide array of diseases, ranging from acute to chronic conditions. A beneficial role of marine drugs in human health has been recently proposed. The current review highlights various marine drugs and their compounds and role in the management of chronic diseases such as cancer, diabetes, neurodegenerative diseases, and cardiovascular disorders, which has led to the development of new drug treatment approaches.
KW - Cancer
KW - Cardiovascular disorders
KW - Diabetes mellitus
KW - Marine drugs
KW - Neurodegeneration
UR - http://www.scopus.com/inward/record.url?scp=85125204000&partnerID=8YFLogxK
U2 - 10.3390/molecules27051539
DO - 10.3390/molecules27051539
M3 - Review article
C2 - 35268639
AN - SCOPUS:85125204000
SN - 1420-3049
VL - 27
JO - Molecules
JF - Molecules
IS - 5
M1 - 1539
ER -