Biosynthesis cobalt-doped nickel nanoparticles and their toxicity against disease

The nanostructures have the great potential for novel medical and drug delivery applications. In present paper a green approach for the preparation of pure nickel oxide (NiO) and 5% cobalt-doped NiO (Co╫NiO) nanoparticles (NPs) by using Prosopis fracta extract have been study. The product of Co╫NiO NPs was proved through the PXRD, Raman, UV–Vis, FESEM, and EDX analyses. The results of XRD, EDX, and UV–Visible spectra displayed well doped cobalt in NiO NP. The particle sizes of Co╫NiO NPs were observed to be about 80 nm. The MTT test results for the cytotoxicity of Co╫NiO NPs on breast cancer cells (MCF-7) affirmed the stronger impact of doped NiO-NPs on cancer cells compared to NiO NPs. Thus, it is indicated that the doping process on NiO NPs caused an increase in its inhibitory effect against MCF-7 cells. Research Highlights: Cobalt-doped NiO nanoparticles were prepared using ecofriendly synthesis method and their cytotoxicity studied against MCF-7 cells.