TY - JOUR
T1 - Autophagy-related chemoradiotherapy sensitivity in non-small cell lung cancer (NSCLC)
AU - Zadeh, Firoozeh Abolhasani
AU - Raji, Ahmed
AU - Ali, Sana Abdul Jabbar
AU - Abdelbasset, Walid Kamal
AU - Alekhina, Natalia
AU - Iswanto, A. Heri
AU - Terefe, Ermias Mergia
AU - Jalil, Abduladheem Turki
N1 - Publisher Copyright:
© 2022
PY - 2022/5
Y1 - 2022/5
N2 - Lung cancer is one of the leading causes of tumor-related mortalities worldwide. NSCLC is the most common type of lung cancer. In recent years, advancements in chemoradiotherapy and immunotherapy have led to unprecedented survival benefits in some patients. However, conventional therapies such as radiation and chemotherapy are not effective in all patients due to the chemo or radioresistance mechanisms; as a result, there is an urgent need for understanding the resistant mechanism. Given that malignancies are caused by changes in cell homeostasis, autophagy may help chemo/radiosensitization by removing damaged compartments and enhancing tumor clearance. Autophagy, on the other hand, may help cancer cells survive by increasing the breakdown of cell cycle regulators. Considering these inconsistencies, this study aimed to overview the intricacy of autophagy in response to chemoradiotherapy in lung cancer.
AB - Lung cancer is one of the leading causes of tumor-related mortalities worldwide. NSCLC is the most common type of lung cancer. In recent years, advancements in chemoradiotherapy and immunotherapy have led to unprecedented survival benefits in some patients. However, conventional therapies such as radiation and chemotherapy are not effective in all patients due to the chemo or radioresistance mechanisms; as a result, there is an urgent need for understanding the resistant mechanism. Given that malignancies are caused by changes in cell homeostasis, autophagy may help chemo/radiosensitization by removing damaged compartments and enhancing tumor clearance. Autophagy, on the other hand, may help cancer cells survive by increasing the breakdown of cell cycle regulators. Considering these inconsistencies, this study aimed to overview the intricacy of autophagy in response to chemoradiotherapy in lung cancer.
KW - Autophagy
KW - Chemotherapy
KW - Lung cancer
KW - NSCLC
KW - Raditherapy
UR - http://www.scopus.com/inward/record.url?scp=85127499595&partnerID=8YFLogxK
U2 - 10.1016/j.prp.2022.153823
DO - 10.1016/j.prp.2022.153823
M3 - Review article
C2 - 35398616
AN - SCOPUS:85127499595
SN - 0344-0338
VL - 233
JO - Pathology Research and Practice
JF - Pathology Research and Practice
M1 - 153823
ER -
