TY - JOUR
T1 - Association between lncRNAs with stem cells in cancer; a particular focus on lncRNA-CSCs axis in cancer immunopathogenesis
AU - Obaid Saleh, Raed
AU - Shbeer, Abdullah M.
AU - Jetti, Raghu
AU - Ahmed Robadi, Ibrahim
AU - Hjazi, Ahmed
AU - Hussein Kareem, Anaheed
AU - Noori Shakir, Maha
AU - Qasim Alasheqi, Mohammed
AU - Alawadi, Ahmed
AU - Haslany, Ali
N1 - Publisher Copyright:
© 2024 Elsevier B.V.
PY - 2024/7/30
Y1 - 2024/7/30
N2 - A unique population of cells known as cancer stem cells (CSCs) is essential to developing and spreading cancer. Cancer initiation, maintenance, and progression are all believed to be significantly impacted by the distinct characteristics these cells exhibit regarding self-renewal, proliferation, and differentiation. Transcriptional, post-transcriptional, and translational processes are the only steps of gene expression that lncRNAs can affect. As a result, these proteins participate in numerous biological processes, including the repair of DNA damage, inflammatory reactions, metabolic control, the survival of cells, intercellular communication, and the development and specialization of cells. Studies have indicated that lncRNAs are important for controlling the increase in the subset of CSCs contributing to cancer development. The knowledge that is currently available about lncRNAs and their critical role in maintaining the biological properties of CSCs is highlighted in this study.
AB - A unique population of cells known as cancer stem cells (CSCs) is essential to developing and spreading cancer. Cancer initiation, maintenance, and progression are all believed to be significantly impacted by the distinct characteristics these cells exhibit regarding self-renewal, proliferation, and differentiation. Transcriptional, post-transcriptional, and translational processes are the only steps of gene expression that lncRNAs can affect. As a result, these proteins participate in numerous biological processes, including the repair of DNA damage, inflammatory reactions, metabolic control, the survival of cells, intercellular communication, and the development and specialization of cells. Studies have indicated that lncRNAs are important for controlling the increase in the subset of CSCs contributing to cancer development. The knowledge that is currently available about lncRNAs and their critical role in maintaining the biological properties of CSCs is highlighted in this study.
KW - Cancer pathogenesis
KW - CSCs
KW - lncRNAs
UR - http://www.scopus.com/inward/record.url?scp=85194923949&partnerID=8YFLogxK
U2 - 10.1016/j.intimp.2024.112306
DO - 10.1016/j.intimp.2024.112306
M3 - Review article
C2 - 38833843
AN - SCOPUS:85194923949
SN - 1567-5769
VL - 136
JO - International Immunopharmacology
JF - International Immunopharmacology
M1 - 112306
ER -
