Application of CRISPR/Cas9 Technology in Cancer Treatment: A Future Direction

  • Ali A. Rabaan
  • , Hajir AlSaihati
  • , Rehab Bukhamsin
  • , Muhammed A. Bakhrebah
  • , Majed S. Nassar
  • , Abdulmonem A. Alsaleh
  • , Yousef N. Alhashem
  • , Ammar Y. Bukhamseen
  • , Khalil Al-Ruhimy
  • , Mohammed Alotaibi
  • , Roua A. Alsubki
  • , Hejji E. Alahmed
  • , Saleh Al-Abdulhadi
  • , Fatemah A. Alhashem
  • , Ahlam A. Alqatari
  • , Ahmed Alsayyah
  • , Ramadan Abdelmoez Farahat
  • , Rwaa H. Abdulal
  • , Ali H. Al-Ahmed
  • , Mohd Imran
  • Ranjan K. Mohapatra

Research output: Contribution to journalReview articlepeer-review

51 Scopus citations

Abstract

Gene editing, especially with clustered regularly interspaced short palindromic repeats associated protein 9 (CRISPR-Cas9), has advanced gene function science. Gene editing’s rapid advancement has increased its medical/clinical value. Due to its great specificity and efficiency, CRISPR/Cas9 can accurately and swiftly screen the whole genome. This simplifies disease-specific gene therapy. To study tumor origins, development, and metastasis, CRISPR/Cas9 can change genomes. In recent years, tumor treatment research has increasingly employed this method. CRISPR/Cas9 can treat cancer by removing genes or correcting mutations. Numerous preliminary tumor treatment studies have been conducted in relevant fields. CRISPR/Cas9 may treat gene-level tumors. CRISPR/Cas9-based personalized and targeted medicines may shape tumor treatment. This review examines CRISPR/Cas9 for tumor therapy research, which will be helpful in providing references for future studies on the pathogenesis of malignancy and its treatment.

Original languageEnglish
Pages (from-to)1954-1976
Number of pages23
JournalCurrent Oncology
Volume30
Issue number2
DOIs
StatePublished - Feb 2023

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

  1. SDG 3 - Good Health and Well-being
    SDG 3 Good Health and Well-being

Keywords

  • CRISPR/Cas
  • advanced technologies
  • advanced therapeutics
  • cancer
  • cancer treatment
  • clinical trials
  • oncoviruses

Fingerprint

Dive into the research topics of 'Application of CRISPR/Cas9 Technology in Cancer Treatment: A Future Direction'. Together they form a unique fingerprint.

Cite this