Antiproliferative triterpenes from Melaleuca ericifolia

Fatma M. Abdel Bar; Ahmed M. Zaghloul; Sunitha V. Bachawal; Paul W. Sylvester; Kadria F. Ahmad; Khalid A. El Sayed

doi:10.1021/np800360a

Antiproliferative triterpenes from Melaleuca ericifolia

Fatma M. Abdel Bar
, Ahmed M. Zaghloul
, Sunitha V. Bachawal
, Paul W. Sylvester
, Kadria F. Ahmad
, Khalid A. El Sayed

University of Louisiana at Monroe
Mansoura University
Qassim University

Research output: Contribution to journal › Article › peer-review

37 Scopus citations

Abstract

Three new 28-noriupane triterpenes, 28-norlup-20(29)-en-3β-hydroxy- 17β-hydroperoxide (1), 28-norlup-20(29)-en-3β-hydroxy-17α- hydroperoxide (2), and 205-17β,29-epoxy-28-norlupan-3β-ol (3), were isolated from the leaves of Melaleuca ericifolia along with eight known pentacyclic triterpenes. The structures of the new compounds were elucidated by spectroscopic methods including 1D and 2D NMR spectroscopy and mass spectrometry. The isolated triterpenes were evaluated for antiproliferative activity against the malignant +SA mammary epithelial cell line.

Original language	English
Pages (from-to)	1787-1790
Number of pages	4
Journal	Journal of Natural Products
Volume	71
Issue number	10
DOIs	https://doi.org/10.1021/np800360a
State	Published - Oct 2008
Externally published	Yes

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10.1021/np800360a

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title = "Antiproliferative triterpenes from Melaleuca ericifolia",

abstract = "Three new 28-noriupane triterpenes, 28-norlup-20(29)-en-3β-hydroxy- 17β-hydroperoxide (1), 28-norlup-20(29)-en-3β-hydroxy-17α- hydroperoxide (2), and 205-17β,29-epoxy-28-norlupan-3β-ol (3), were isolated from the leaves of Melaleuca ericifolia along with eight known pentacyclic triterpenes. The structures of the new compounds were elucidated by spectroscopic methods including 1D and 2D NMR spectroscopy and mass spectrometry. The isolated triterpenes were evaluated for antiproliferative activity against the malignant +SA mammary epithelial cell line.",

author = "\{Abdel Bar\}, \{Fatma M.\} and Zaghloul, \{Ahmed M.\} and Bachawal, \{Sunitha V.\} and Sylvester, \{Paul W.\} and Ahmad, \{Kadria F.\} and \{El Sayed\}, \{Khalid A.\}",

year = "2008",

month = oct,

doi = "10.1021/np800360a",

language = "English",

volume = "71",

pages = "1787--1790",

journal = "Journal of Natural Products",

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TY - JOUR

T1 - Antiproliferative triterpenes from Melaleuca ericifolia

AU - Abdel Bar, Fatma M.

AU - Zaghloul, Ahmed M.

AU - Bachawal, Sunitha V.

AU - Sylvester, Paul W.

AU - Ahmad, Kadria F.

AU - El Sayed, Khalid A.

PY - 2008/10

Y1 - 2008/10

N2 - Three new 28-noriupane triterpenes, 28-norlup-20(29)-en-3β-hydroxy- 17β-hydroperoxide (1), 28-norlup-20(29)-en-3β-hydroxy-17α- hydroperoxide (2), and 205-17β,29-epoxy-28-norlupan-3β-ol (3), were isolated from the leaves of Melaleuca ericifolia along with eight known pentacyclic triterpenes. The structures of the new compounds were elucidated by spectroscopic methods including 1D and 2D NMR spectroscopy and mass spectrometry. The isolated triterpenes were evaluated for antiproliferative activity against the malignant +SA mammary epithelial cell line.

AB - Three new 28-noriupane triterpenes, 28-norlup-20(29)-en-3β-hydroxy- 17β-hydroperoxide (1), 28-norlup-20(29)-en-3β-hydroxy-17α- hydroperoxide (2), and 205-17β,29-epoxy-28-norlupan-3β-ol (3), were isolated from the leaves of Melaleuca ericifolia along with eight known pentacyclic triterpenes. The structures of the new compounds were elucidated by spectroscopic methods including 1D and 2D NMR spectroscopy and mass spectrometry. The isolated triterpenes were evaluated for antiproliferative activity against the malignant +SA mammary epithelial cell line.

UR - https://www.scopus.com/pages/publications/56049109975

U2 - 10.1021/np800360a

DO - 10.1021/np800360a

M3 - Article

C2 - 18826277

AN - SCOPUS:56049109975

SN - 0163-3864

VL - 71

SP - 1787

EP - 1790

JO - Journal of Natural Products

JF - Journal of Natural Products

IS - 10

ER -

Antiproliferative triterpenes from Melaleuca ericifolia

Abstract

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