Antimycobacterial Evaluation and Microwave-Assisted Synthesis of N-(5-methyl-4-oxo-2-arylthiazolidin-3-yl) Isonicotinamide Derivatives

Thiazolidinone derivatives represent heterocyclic bioactive compounds. We have synthesized some N-(5-methyl-4-oxo-2-arylthiazolidin-3-yl)-isonicotinamide derivatives (2a–2h) from isoniazid (INH) and screened them as antimycobacterial agents against M. tuberculosis H37Rv strain using microplate alamar blue assay (MABA). Compounds 2a-2h were obtained via cyclocondensation of N-arylideneisonicotinohydrazide derivatives (imine Schiff’s bases) 1a-1h with thiolactic acid. Initial compounds 1a-1h were synthesized by reaction of isoniazid with appropriate benzaldehyde. The structures of title compounds were established by IR, 1H NMR, and mass spectroscopy data. All the title compounds (2a-2h) exhibited antimycobacterial activity and were compared to standard drugs streptomycin (MIC value of 6.25 μg/mL) and isoniazid (MIC value of 3.125 μg/mL). Compound 2g exhibited the highest antimycobacterial activity, but all the tested compounds were less active than standard drugs.