TY - JOUR
T1 - Antihyperhomocysteinemic activity of an ethanol extract from Embelia ribes in albino rats
AU - Ansari, M. Nazam
AU - Bhandari, U.
PY - 2008/4
Y1 - 2008/4
N2 - An ethanol extract from Embelia ribes Burm (Myrsinaceae) fruits was investigated for its antihyperhomocysteinemic and lipid-lowering potential in methionine-induced hyperhomocysteinemia rats. Hyperhomocysteinemia was induced by methionine (1 g/kg, p.o., 30 days) through drinking water in male albino rats. A significant (p < 0.01) increase in homocysteine, lactate dehydrogenase, total cholesterol, triglycerides, and low-density lipoprotein levels in serum and lipid peroxides levels in heart homogenates with a concomitant decrease in serum high-density lipoprotein and myocardial glutathione levels were observed in pathogenic control rats compared with normal healthy control rats. Furthermore, ethanol Embelia ribes extract (100 and 200 mg/kg, p.o., 30 days) treatment in both the doses significantly reversed all the above-mentioned parameters compared with pathogenic control rats. The results of test drug were comparable with folic acid (100 mg/kg, p.o.), a standard antihyperhomocysteinemic agent. The results indicated that ethanol Embelia ribes extract has significant antihyperhomocysteinemic and lipid-lowering potential in hyperhomocysteinemic rats.
AB - An ethanol extract from Embelia ribes Burm (Myrsinaceae) fruits was investigated for its antihyperhomocysteinemic and lipid-lowering potential in methionine-induced hyperhomocysteinemia rats. Hyperhomocysteinemia was induced by methionine (1 g/kg, p.o., 30 days) through drinking water in male albino rats. A significant (p < 0.01) increase in homocysteine, lactate dehydrogenase, total cholesterol, triglycerides, and low-density lipoprotein levels in serum and lipid peroxides levels in heart homogenates with a concomitant decrease in serum high-density lipoprotein and myocardial glutathione levels were observed in pathogenic control rats compared with normal healthy control rats. Furthermore, ethanol Embelia ribes extract (100 and 200 mg/kg, p.o., 30 days) treatment in both the doses significantly reversed all the above-mentioned parameters compared with pathogenic control rats. The results of test drug were comparable with folic acid (100 mg/kg, p.o.), a standard antihyperhomocysteinemic agent. The results indicated that ethanol Embelia ribes extract has significant antihyperhomocysteinemic and lipid-lowering potential in hyperhomocysteinemic rats.
KW - Embelia ribes
KW - Homocysteine
KW - Lipid profiles
KW - Methionine
UR - http://www.scopus.com/inward/record.url?scp=41349083588&partnerID=8YFLogxK
U2 - 10.1080/13880200701741146
DO - 10.1080/13880200701741146
M3 - Article
AN - SCOPUS:41349083588
SN - 1388-0209
VL - 46
SP - 283
EP - 287
JO - Pharmaceutical Biology
JF - Pharmaceutical Biology
IS - 4
ER -