Anticancer properties of sulforaphane: current insights at the molecular level

Muhammad Asif Ali; Noohela Khan; Nabeeha Kaleem; Waqas Ahmad; Salem Hussain Alharethi; Bandar Alharbi; Hassan H. Alhassan; Maher M. Al-Enazi; Ahmad Faizal Abdull Razis; Babagana Modu; Daniela Calina; Javad Sharifi-Rad

doi:10.3389/fonc.2023.1168321

Anticancer properties of sulforaphane: current insights at the molecular level

Muhammad Asif Ali, Noohela Khan, Nabeeha Kaleem, Waqas Ahmad, Salem Hussain Alharethi, Bandar Alharbi, Hassan H. Alhassan, Maher M. Al-Enazi, Ahmad Faizal Abdull Razis, Babagana Modu, Daniela Calina, Javad Sharifi-Rad

Medical Laboratory Sciences

Research output: Contribution to journal › Review article › peer-review

40 Scopus citations

Abstract

Sulforaphane (SFN) is an isothiocyanate with multiple biomedical applications. Sulforaphane can be extracted from the plants of the genus Brassica. However, broccoli sprouts are the chief source of sulforaphane and are 20 to 50 times richer than mature broccoli as they contain 1,153 mg/100 g. SFN is a secondary metabolite that is produced as a result of the hydrolysis of glucoraphanin (a glucosinolate) by the enzyme myrosinase. This review paper aims to summarize and understand the mechanisms behind the anticancer potential of sulforaphane. The data was collected by searching PubMed/MedLine, Scopus, Web of Science, and Google Scholar. This paper concludes that sulforaphane provides cancer protection through the alteration of various epigenetic and non-epigenetic pathways. It is a potent anticancer phytochemical that is safe to consume with minimal side effects. However, there is still a need for further research regarding SFN and the development of a standard dose.

Original language	English
Article number	1168321
Journal	Frontiers in Oncology
Volume	13
DOIs	https://doi.org/10.3389/fonc.2023.1168321
State	Published - 2023

Keywords

anticancer mechanisms
apoptosis
cytotoxicity
isothiocyanate
sulforaphane

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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title = "Anticancer properties of sulforaphane: current insights at the molecular level",

abstract = "Sulforaphane (SFN) is an isothiocyanate with multiple biomedical applications. Sulforaphane can be extracted from the plants of the genus Brassica. However, broccoli sprouts are the chief source of sulforaphane and are 20 to 50 times richer than mature broccoli as they contain 1,153 mg/100 g. SFN is a secondary metabolite that is produced as a result of the hydrolysis of glucoraphanin (a glucosinolate) by the enzyme myrosinase. This review paper aims to summarize and understand the mechanisms behind the anticancer potential of sulforaphane. The data was collected by searching PubMed/MedLine, Scopus, Web of Science, and Google Scholar. This paper concludes that sulforaphane provides cancer protection through the alteration of various epigenetic and non-epigenetic pathways. It is a potent anticancer phytochemical that is safe to consume with minimal side effects. However, there is still a need for further research regarding SFN and the development of a standard dose.",

keywords = "anticancer mechanisms, apoptosis, cytotoxicity, isothiocyanate, sulforaphane",

author = "\{Asif Ali\}, Muhammad and Noohela Khan and Nabeeha Kaleem and Waqas Ahmad and Alharethi, \{Salem Hussain\} and Bandar Alharbi and Alhassan, \{Hassan H.\} and Al-Enazi, \{Maher M.\} and Razis, \{Ahmad Faizal Abdull\} and Babagana Modu and Daniela Calina and Javad Sharifi-Rad",

note = "Publisher Copyright: Copyright {\textcopyright} 2023 Asif Ali, Khan, Kaleem, Ahmad, Alharethi, Alharbi, Alhassan, Al-Enazi, Razis, Modu, Calina and Sharifi-Rad.",

year = "2023",

doi = "10.3389/fonc.2023.1168321",

language = "English",

volume = "13",

journal = "Frontiers in Oncology",

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T1 - Anticancer properties of sulforaphane

T2 - current insights at the molecular level

AU - Asif Ali, Muhammad

AU - Khan, Noohela

AU - Kaleem, Nabeeha

AU - Ahmad, Waqas

AU - Alharethi, Salem Hussain

AU - Alharbi, Bandar

AU - Alhassan, Hassan H.

AU - Al-Enazi, Maher M.

AU - Razis, Ahmad Faizal Abdull

AU - Modu, Babagana

AU - Calina, Daniela

AU - Sharifi-Rad, Javad

PY - 2023

Y1 - 2023

N2 - Sulforaphane (SFN) is an isothiocyanate with multiple biomedical applications. Sulforaphane can be extracted from the plants of the genus Brassica. However, broccoli sprouts are the chief source of sulforaphane and are 20 to 50 times richer than mature broccoli as they contain 1,153 mg/100 g. SFN is a secondary metabolite that is produced as a result of the hydrolysis of glucoraphanin (a glucosinolate) by the enzyme myrosinase. This review paper aims to summarize and understand the mechanisms behind the anticancer potential of sulforaphane. The data was collected by searching PubMed/MedLine, Scopus, Web of Science, and Google Scholar. This paper concludes that sulforaphane provides cancer protection through the alteration of various epigenetic and non-epigenetic pathways. It is a potent anticancer phytochemical that is safe to consume with minimal side effects. However, there is still a need for further research regarding SFN and the development of a standard dose.

AB - Sulforaphane (SFN) is an isothiocyanate with multiple biomedical applications. Sulforaphane can be extracted from the plants of the genus Brassica. However, broccoli sprouts are the chief source of sulforaphane and are 20 to 50 times richer than mature broccoli as they contain 1,153 mg/100 g. SFN is a secondary metabolite that is produced as a result of the hydrolysis of glucoraphanin (a glucosinolate) by the enzyme myrosinase. This review paper aims to summarize and understand the mechanisms behind the anticancer potential of sulforaphane. The data was collected by searching PubMed/MedLine, Scopus, Web of Science, and Google Scholar. This paper concludes that sulforaphane provides cancer protection through the alteration of various epigenetic and non-epigenetic pathways. It is a potent anticancer phytochemical that is safe to consume with minimal side effects. However, there is still a need for further research regarding SFN and the development of a standard dose.

KW - anticancer mechanisms

KW - apoptosis

KW - cytotoxicity

KW - isothiocyanate

KW - sulforaphane

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DO - 10.3389/fonc.2023.1168321

M3 - Review article

AN - SCOPUS:85164411933

SN - 2234-943X

VL - 13

JO - Frontiers in Oncology

JF - Frontiers in Oncology

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ER -

Anticancer properties of sulforaphane: current insights at the molecular level

Abstract

Keywords

UN SDGs

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