Anticancer potentiated bioactive compounds from marine flora

Arun Kumar Ramu, Ranjani Rajendran, Azhagu Madhavan Sivalingam, V. D. Seshadri, Abdul Bakrudeen Ali Ahmed

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

2 Scopus citations

Abstract

Cancer is responsible for around one of every six deaths around the world. It is the driving reason for death internationally, with 8.7 million deaths in 2015. Factors that increase the risk of cancer include tobacco use (22% of cancer death), alcohol consuming, poor nutrients diet, a sedentary lifestyle of the human. These elements are believed to account for roughly 33% of cancer deaths. The most common malignancies in women are breast, cervical, lung, thyroid, and colorectal cancers, whereas prostate, lung, colorectal, liver, and stomach cancers are the most common cancers in men. Although several techniques are used in treating cancer, including radiation treatment, medical procedures, immunotherapy, and endocrine treatment, chemotherapy is the most widely recognized form of cancer therapy. Recent research shows that more than 90% of cancer deaths can be ascribed to drug resistance. There are a variety of methods for treating cancer patients with advanced stages, such as inhibiting drug efflux protein, suppressing DNA repair factors, and down-regulated abnormal xenobiotic metabolism. However, clinical utilization of synthetic drugs is associated with undesirable impacts such as suppression of bone marrow, gastrointestinal ulcers, neurological disorders, and cardiac toxicity. Cancer-related death rates are observed to remain high, with little attention given to substantial research and investigation efforts with medically innovative clinical underpinnings that make use of new pharmacological agents.

Original languageEnglish
Title of host publicationMarine Antioxidants
Subtitle of host publicationPreparations, Syntheses, and Applications
PublisherElsevier
Pages421-432
Number of pages12
ISBN (Electronic)9780323950862
DOIs
StatePublished - 1 Jan 2022

Keywords

  • Epidermal growth factor receptor (EGFR)
  • Multidrug Resistance Cancer
  • Reactive Oxygen Species (ROS)
  • Transforming growth factor beta (TGF-β)

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