An updated view: Pathogenicity of helicobacter pylori microbial infection in chronic kidney disease and end stage kidney dysfunction (esrd) under oxidative stress

Helicobacter pylori is a Gram-negative, flagellated, microaerophilic bacterium, which particularly found in the human stomach. Pro-as well as anti-inflammatory cytokines along with oxidative stress is a crucial factor in the progress of peptic and gastric ulceration as well as gastric carcinoma in subjects having chronic H. pylori microbial infection. H. pylori eradication from gastrointestinal tract (GIT) is liable for neuroendocrine modification because of a stressful feedback of the host and is an indication for initiating growth and pathogenic progress in body organs. The importance of H. pylori infection to renal dysfunction under oxidative stress condition is still unclear and almost untouched area. In a recent research study, H. pylori infected patients with coexistence of chronic kidney infectious disease (CKD) and cardiovascular diseases risk factors may be at surpassing risk of end stage renal disease (ESRD). However, it is hardly known about the fact whether eradication of the bacteria has any consequence on renal function under oxidative stress condition or not. Therefore, the present study anticipated this review along with extra gastric H. pylori infection with progressive development of chronic kidney diseases and advancement to ESRD, under oxidative stress condition.