An overview on COVID-19 and vaccines: findings and learnings from the pandemic

The coronavirus-2019 (COVID-19) pandemic continues to create global impact and continues to stand divided on the mask mandate, the vaccine passport, and the continuous testing process. The focus of this review is to highlight the hematological findings in COVID-19, complications, as well as impact of vaccinations. A detailed literature review has been conducted using keywords including “coronavirus disease”, “COVID-19”, “COVID-19 vaccinations”, “COVID-19 hematological complications” to list a few. The findings highlight mutations in the non-structural proteins NSP2 and NSP3 to be crucial. With over fifty potential vaccine candidates in trial, prevention and symptom management continue to be the primary clinical challenge. Clinical studies have detailed the hematological complications of COVID-19, including coagulopathy, lymphopenia, and changes in levels of platelet, blood cells, and hemoglobin, to state a few. Further, we also discuss the impact of vaccination on hemolysis, on multiple myeloma patients, as well as thrombocytopenia.