Ameliorative effects of Cuscuta reflexa and Peucedanum grande on letrozole induced polycystic ovary syndrome in Wistar rats

Firdaus Kausar; Muzafar Ahmad Rather; Showkeen Muzamil Bashir; Rana M. Alsaffar; Showkat ul Nabi; Sofi Imtiyaz Ali; Pankaj Goswami; Ansar Ahmad; Summya Rashid; Adil Farooq Wali

doi:10.1080/13510002.2021.1927396

Ameliorative effects of Cuscuta reflexa and Peucedanum grande on letrozole induced polycystic ovary syndrome in Wistar rats

Firdaus Kausar, Muzafar Ahmad Rather, Showkeen Muzamil Bashir, Rana M. Alsaffar, Showkat ul Nabi, Sofi Imtiyaz Ali, Pankaj Goswami, Ansar Ahmad, Summya Rashid, Adil Farooq Wali

Pharmacology

Research output: Contribution to journal › Article › peer-review

16 Scopus citations

Abstract

Objectives: The current study was designed to examine the therapeutic role of hydroalcoholic extract of Cuscuta reflexa Roxb (CRE) and Peucedanum grande C.B. Clarke (PGE) on letrozole (1 mg/kg) induced polycystic ovary syndrome (PCOS) in female Wistar albino rats. Methods: PCOS rats were treated with CRE (280 mg/kg), PGE (140 mg/kg) or CRE + PGE p.o. for 3 weeks. Vaginal smears for phase of estrous cycle determination, serum levels of sex androgens, lipid profile, oxidative stress parameters and histopathology of ovarian tissues were investigated. Results: Diestrous cycle days treated with CRE (group III) or PGE (group IV) decreased significantly (p < 0.05) compared to PCOS control animals (group II). Moreover, weight of uteri in PCOS animals treated with the plant extracts also increased significantly (p < 0.05) compared to that of group II animals. Histopathological examination showed the protective effect of the CRE and PGE indicated by the disappearance of ovarian cyst. Conclusion: The study demonstrated that the CRE and PGE either alone or in combination hold a significant effect in letrozole induced PCOS rat models and could be useful in the management of reproductive and metabolic disorders related to PCOS.

Original language	English
Pages (from-to)	94-104
Number of pages	11
Journal	Redox Report
Volume	26
Issue number	1
DOIs	https://doi.org/10.1080/13510002.2021.1927396
State	Published - 2021

Keywords

diestrous cycle
histopathological examination
hydroalcoholic extract
Metabolic disorders

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10.1080/13510002.2021.1927396

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title = "Ameliorative effects of Cuscuta reflexa and Peucedanum grande on letrozole induced polycystic ovary syndrome in Wistar rats",

abstract = "Objectives: The current study was designed to examine the therapeutic role of hydroalcoholic extract of Cuscuta reflexa Roxb (CRE) and Peucedanum grande C.B. Clarke (PGE) on letrozole (1 mg/kg) induced polycystic ovary syndrome (PCOS) in female Wistar albino rats. Methods: PCOS rats were treated with CRE (280 mg/kg), PGE (140 mg/kg) or CRE + PGE p.o. for 3 weeks. Vaginal smears for phase of estrous cycle determination, serum levels of sex androgens, lipid profile, oxidative stress parameters and histopathology of ovarian tissues were investigated. Results: Diestrous cycle days treated with CRE (group III) or PGE (group IV) decreased significantly (p < 0.05) compared to PCOS control animals (group II). Moreover, weight of uteri in PCOS animals treated with the plant extracts also increased significantly (p < 0.05) compared to that of group II animals. Histopathological examination showed the protective effect of the CRE and PGE indicated by the disappearance of ovarian cyst. Conclusion: The study demonstrated that the CRE and PGE either alone or in combination hold a significant effect in letrozole induced PCOS rat models and could be useful in the management of reproductive and metabolic disorders related to PCOS.",

keywords = "diestrous cycle, histopathological examination, hydroalcoholic extract, Metabolic disorders",

author = "Firdaus Kausar and Rather, \{Muzafar Ahmad\} and Bashir, \{Showkeen Muzamil\} and Alsaffar, \{Rana M.\} and Nabi, \{Showkat ul\} and Ali, \{Sofi Imtiyaz\} and Pankaj Goswami and Ansar Ahmad and Summya Rashid and Wali, \{Adil Farooq\}",

note = "Publisher Copyright: {\textcopyright} 2021 The Author(s). Published by Informa UK Limited, trading as Taylor \& Francis Group.",

year = "2021",

doi = "10.1080/13510002.2021.1927396",

language = "English",

volume = "26",

pages = "94--104",

journal = "Redox Report",

issn = "1351-0002",

publisher = "Taylor and Francis Ltd.",

number = "1",

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T1 - Ameliorative effects of Cuscuta reflexa and Peucedanum grande on letrozole induced polycystic ovary syndrome in Wistar rats

AU - Kausar, Firdaus

AU - Rather, Muzafar Ahmad

AU - Bashir, Showkeen Muzamil

AU - Alsaffar, Rana M.

AU - Nabi, Showkat ul

AU - Ali, Sofi Imtiyaz

AU - Goswami, Pankaj

AU - Ahmad, Ansar

AU - Rashid, Summya

AU - Wali, Adil Farooq

PY - 2021

Y1 - 2021

N2 - Objectives: The current study was designed to examine the therapeutic role of hydroalcoholic extract of Cuscuta reflexa Roxb (CRE) and Peucedanum grande C.B. Clarke (PGE) on letrozole (1 mg/kg) induced polycystic ovary syndrome (PCOS) in female Wistar albino rats. Methods: PCOS rats were treated with CRE (280 mg/kg), PGE (140 mg/kg) or CRE + PGE p.o. for 3 weeks. Vaginal smears for phase of estrous cycle determination, serum levels of sex androgens, lipid profile, oxidative stress parameters and histopathology of ovarian tissues were investigated. Results: Diestrous cycle days treated with CRE (group III) or PGE (group IV) decreased significantly (p < 0.05) compared to PCOS control animals (group II). Moreover, weight of uteri in PCOS animals treated with the plant extracts also increased significantly (p < 0.05) compared to that of group II animals. Histopathological examination showed the protective effect of the CRE and PGE indicated by the disappearance of ovarian cyst. Conclusion: The study demonstrated that the CRE and PGE either alone or in combination hold a significant effect in letrozole induced PCOS rat models and could be useful in the management of reproductive and metabolic disorders related to PCOS.

AB - Objectives: The current study was designed to examine the therapeutic role of hydroalcoholic extract of Cuscuta reflexa Roxb (CRE) and Peucedanum grande C.B. Clarke (PGE) on letrozole (1 mg/kg) induced polycystic ovary syndrome (PCOS) in female Wistar albino rats. Methods: PCOS rats were treated with CRE (280 mg/kg), PGE (140 mg/kg) or CRE + PGE p.o. for 3 weeks. Vaginal smears for phase of estrous cycle determination, serum levels of sex androgens, lipid profile, oxidative stress parameters and histopathology of ovarian tissues were investigated. Results: Diestrous cycle days treated with CRE (group III) or PGE (group IV) decreased significantly (p < 0.05) compared to PCOS control animals (group II). Moreover, weight of uteri in PCOS animals treated with the plant extracts also increased significantly (p < 0.05) compared to that of group II animals. Histopathological examination showed the protective effect of the CRE and PGE indicated by the disappearance of ovarian cyst. Conclusion: The study demonstrated that the CRE and PGE either alone or in combination hold a significant effect in letrozole induced PCOS rat models and could be useful in the management of reproductive and metabolic disorders related to PCOS.

KW - diestrous cycle

KW - histopathological examination

KW - hydroalcoholic extract

KW - Metabolic disorders

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DO - 10.1080/13510002.2021.1927396

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AN - SCOPUS:85106631190

SN - 1351-0002

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EP - 104

JO - Redox Report

JF - Redox Report

IS - 1

ER -

Ameliorative effects of Cuscuta reflexa and Peucedanum grande on letrozole induced polycystic ovary syndrome in Wistar rats

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