TY - JOUR
T1 - Advances in chitosan-based hydrogels for pharmaceutical and biomedical applications
T2 - A comprehensive review
AU - Almajidi, Yasir Qasim
AU - Gupta, Jitendra
AU - Sheri, Fatime Satar
AU - Zabibah, Rahman S.
AU - Faisal, Ahmed
AU - Ruzibayev, Akbarali
AU - Adil, Mohaned
AU - Saadh, Mohamed J.
AU - Jawad, Mahmood Jasem
AU - Alsaikhan, Fahad
AU - Narmani, Asghar
AU - Farhood, Bagher
N1 - Publisher Copyright:
© 2023
PY - 2023/12/31
Y1 - 2023/12/31
N2 - The treatment of diseases, such as cancer, is one of the most significant issues correlated with human beings health. Hydrogels (HGs) prepared from biocompatible and biodegradable materials, especially biopolymers, have been effectively employed for the sort of pharmaceutical and biomedical applications, including drug delivery systems, biosensors, and tissue engineering. Chitosan (CS), one of the most abundant bio-polysaccharide derived from chitin, is an efficient biomaterial in the prognosis, diagnosis, and treatment of diseases. CS-based HGs possess some potential advantages, like high values of bioactive encapsulation, efficient drug delivery to a target site, sustained drug release, good biocompatibility and biodegradability, high serum stability, non-immunogenicity, etc., which made them practical and useful for pharmaceutical and biomedical applications. In this review, we summarize recent achievements and advances associated with CS-based HGs for drug delivery, regenerative medicine, disease detection and therapy.
AB - The treatment of diseases, such as cancer, is one of the most significant issues correlated with human beings health. Hydrogels (HGs) prepared from biocompatible and biodegradable materials, especially biopolymers, have been effectively employed for the sort of pharmaceutical and biomedical applications, including drug delivery systems, biosensors, and tissue engineering. Chitosan (CS), one of the most abundant bio-polysaccharide derived from chitin, is an efficient biomaterial in the prognosis, diagnosis, and treatment of diseases. CS-based HGs possess some potential advantages, like high values of bioactive encapsulation, efficient drug delivery to a target site, sustained drug release, good biocompatibility and biodegradability, high serum stability, non-immunogenicity, etc., which made them practical and useful for pharmaceutical and biomedical applications. In this review, we summarize recent achievements and advances associated with CS-based HGs for drug delivery, regenerative medicine, disease detection and therapy.
KW - Biosensors
KW - Chitosan hydrogels
KW - Disease therapy
KW - Pharmaceutical application
KW - Preparation and modification
KW - Regenerative medicine
UR - http://www.scopus.com/inward/record.url?scp=85173829308&partnerID=8YFLogxK
U2 - 10.1016/j.ijbiomac.2023.127278
DO - 10.1016/j.ijbiomac.2023.127278
M3 - Review article
C2 - 37806412
AN - SCOPUS:85173829308
SN - 0141-8130
VL - 253
JO - International Journal of Biological Macromolecules
JF - International Journal of Biological Macromolecules
M1 - 127278
ER -
