TY - JOUR
T1 - Acemannan ameliorates STZ-activated diabetes by attenuating high glucose via inhibiting inflammatory cytokines and apoptosis pathway
AU - Omer, Asma B.
AU - Altayb, Hisham N.
AU - Al-Abbasi, Fahad A.
AU - Gupta, Gaurav
AU - Ahmed, Mohammed Muqtader
AU - Alghamdi, Amira M.
AU - Alzarea, Sami I.
AU - Sayyed, Nadeem
AU - Nadeem, Muhammad Shahid
AU - Kazmi, Imran
N1 - Publisher Copyright:
© 2023 Elsevier B.V.
PY - 2023/12/31
Y1 - 2023/12/31
N2 - Acemannan, the main polysaccharide in Aloe vera, is a -(1, 4)-acetylated polymannose. According to numerous research findings, acemannan is a viable alternative for the treatment of pathological disorders. Streptozotocin (STZ, 60 mg/kg) administered intraperitoneally caused type 2 diabetes in rats. The current study sought to determine the anti-diabetic efficacy of acemannan (25 and 50 mg/kg) in STZ-injected rats. Different biochemical parameters including HbA1C, glucose and serum insulin, lipid profile, inflammatory markers, antioxidant, oxidative balance, liver function test, glycogen and creatinine, and caspase-3 were evaluated. In addition, a molecular docking study was performed to estimate acemannan's binding affinity to inflammatory markers. Acemannan may be a potent anti-diabetic agent for the treatment of diabetic patients, which will aid in future research into alternative diabetes medications.
AB - Acemannan, the main polysaccharide in Aloe vera, is a -(1, 4)-acetylated polymannose. According to numerous research findings, acemannan is a viable alternative for the treatment of pathological disorders. Streptozotocin (STZ, 60 mg/kg) administered intraperitoneally caused type 2 diabetes in rats. The current study sought to determine the anti-diabetic efficacy of acemannan (25 and 50 mg/kg) in STZ-injected rats. Different biochemical parameters including HbA1C, glucose and serum insulin, lipid profile, inflammatory markers, antioxidant, oxidative balance, liver function test, glycogen and creatinine, and caspase-3 were evaluated. In addition, a molecular docking study was performed to estimate acemannan's binding affinity to inflammatory markers. Acemannan may be a potent anti-diabetic agent for the treatment of diabetic patients, which will aid in future research into alternative diabetes medications.
KW - Acemannan
KW - Apoptosis
KW - Docking study
KW - Polysaccharide
KW - Streptozotocin
UR - http://www.scopus.com/inward/record.url?scp=85173170165&partnerID=8YFLogxK
U2 - 10.1016/j.ijbiomac.2023.127127
DO - 10.1016/j.ijbiomac.2023.127127
M3 - Article
C2 - 37776926
AN - SCOPUS:85173170165
SN - 0141-8130
VL - 253
JO - International Journal of Biological Macromolecules
JF - International Journal of Biological Macromolecules
M1 - 127127
ER -
